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Titolo:
PET IMAGING OF NEOCORTICAL MONOAMINERGIC TERMINALS IN PARKINSONS-DISEASE
Autore:
MARIE RM; BARRE L; RIOUX P; ALLAIN P; LECHEVALIER B; BARON JC;
Indirizzi:
CYCERON,INSERM,U320,BLVD H BECQUEREL,BP 5229 F-14074 CAEN FRANCE CHU CAEN,CYCERON CAEN FRANCE CHU CAEN,INSERM,U320 CAEN FRANCE CHU CAEN,SERV NEUROL DEJERINE CAEN FRANCE UNIV CAEN,CEA,DSV,DRIPP F-14032 CAEN FRANCE
Titolo Testata:
Journal of neural transmission. Parkinson's disease and dementia section
fascicolo: 1, volume: 9, anno: 1995,
pagine: 55 - 71
SICI:
0936-3076(1995)9:1<55:PIONMT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; STRIATAL DOPAMINERGIC SYSTEM; H-3 GBR-12935 BINDING; HUMAN CEREBRAL-CORTEX; BLOOD-FLOW; PREFRONTAL CORTEX; SITES; METABOLISM; INVIVO; BRAIN;
Keywords:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE; NOREPINEPHRINE; C-11 NOMIFENSINE; REUPTAKE SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Marie et al., "PET IMAGING OF NEOCORTICAL MONOAMINERGIC TERMINALS IN PARKINSONS-DISEASE", Journal of neural transmission. Parkinson's disease and dementia section, 9(1), 1995, pp. 55-71

Abstract

Post-mortem neurochemical studies in Parkinson's disease (PD) have shown that, in addition to the typical nigro-striatal dopamine denervation, there exists a concomitant neocortical monoamine fibre deafferentation (of variable severity) whose role in motor, and especially in associated cognitive and affective impairment, remains elusive. We have extensively examined whether PET imaging with C-11-S-Nomifensine (C-11-NMF), a radioligand of the dopamine and norepinephrine presynaptic reuptake sites which has been used so far to investigate the striatum, could provide a method for assessing in vivo the neocortical monoamine terminal loss in PD; previously, this has been a little addressed and controversial issue. To this end, we prospectively selected a highly homogeneous sample of nine non-demented, non-depressed idiopathic PD patients with mild to marked side-to-side asymmetry in motor impairment. In addition to recovering the previously-reported correlations with putaminal C-11-NMF specific uptake asymmetries, the clinical motor asymmetries also significantly correlated in the clinically expected direction to neocortical (especially frontal) C-11-NMF asymmetries, suggesting the monoamine neocortical denervation might play a direct role in motor impairment in PD. These results demonstrate that it is possible to assess in vivo the neocortical monoamine terminal loss, and to elucidate its potential role in the complex cognitive and affective impairment, in both PD and atypical degenerative parkinsonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:46:08