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Titolo:
RECURRENT SECONDARY HYPERPARATHYROIDISM DUE TO PARATHYROID CARCINOMA - USEFULNESS OF KI-67 IMMUNOSTAINING IN THE DIAGNOSIS OF A MALIGNANT PARATHYROID TUMOR
Autore:
DIONISIO P; STRAMIGNONI E; PASSARINO G; PUCCI A; VALENTI M; BERTO IM; BARBOS MP; CADARIO A; GASPARRI G; BAJARDI P;
Indirizzi:
OSPED INFERM BIELLA,DEPT NEPHROL,VIA CARACCIO N 5 I-13051 BIELLA ITALY INFERMI HOSP,DEPT NEPHROL & DIALYSIS BIELLA ITALY UNIV TURIN,SCH MED,DEPT BIOMED SCI TURIN ITALY UNIV TURIN,SCH MED,DEPT BIOMED SCI & ONCOL,SECT MORBID ANAT & HISTOPATHOL TURIN ITALY ST GIOVANNI HOSP TURIN ITALY UNIV TURIN,ST LUIGI GONZAGA HOSP,DEPT CLIN & BIOL SCI,DIV ORTHOPAED TURIN ITALY UNIV TURIN,ST GIOVANNI HOSP,DEPT SURG 3 TURIN ITALY
Titolo Testata:
Nephron
fascicolo: 4, volume: 74, anno: 1996,
pagine: 720 - 723
SICI:
0028-2766(1996)74:4<720:RSHDTP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY KI-67;
Keywords:
HEMODIALYSIS; HYPERPARATHYROIDISM; KI-67 ANTIGEN; PARATHYROID CARCINOMA; PARATHYROID HORMONE; TUMOR PROLIFERATIVE FRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
P. Dionisio et al., "RECURRENT SECONDARY HYPERPARATHYROIDISM DUE TO PARATHYROID CARCINOMA - USEFULNESS OF KI-67 IMMUNOSTAINING IN THE DIAGNOSIS OF A MALIGNANT PARATHYROID TUMOR", Nephron, 74(4), 1996, pp. 720-723

Abstract

Parathyroid carcinoma is a very rare disease occurring in less than 2-3% of all the cases showing clinical features of primary hyperparathyroidism. Several histological markers have been used for distinguishing between benign and malignant tumors of the parathyroid glands. However, most of these markers are not easily applicable and clinical prognosis cannot be predicted by histopathological criteria alone. A recentstudy has drawn attention to the role of the cell cycle associated antigen Ki-67 detected by MIB-1 monoclonal immunocytochemistry in parathyroid tumors: in fact, Ki-67 seems to be a valuable marker of malignancy in such tumors since it permits an easy detection of proliferating and dividing cells. Here we report in detail a case of severe recurrent hyperparathyroidism in a 51-year-old female patient undergoing regular hemodialysis treatment. In the surgical specimens of the parathyroid glands, the tumor proliferative fraction of 56, expressed as the number of Ki-67-positive nuclei per thousand cells, and the mean mitosis count of 0.5, expressed as the percentage of the total amount of Ki-67positive nuclei, support the diagnosis of parathyroid carcinoma despite the scanty amount of microscopical signs considered characteristic of malignancy, i.e. extensive thick fibrous bands or prominent nucleoli. To our knowledge this paper is the first clinical report that supports the diagnostic role of the cell cycle associated antigen Ki-67 in parathyroid carcinoma in a case of secondary hyperparathyroidism in a patient undergoing hemodialysis.

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Documento generato il 27/11/20 alle ore 07:28:42