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Titolo:
GLUTAMATE DOPAMINE D-1 D-2 BALANCE IN THE BASAL GANGLIA AND ITS RELEVANCE TO PARKINSONS-DISEASE/
Autore:
STARR MS;
Indirizzi:
UNIV LONDON,SCH PHARM,DEPT PHARMACOL LONDON WC1N 1AX ENGLAND
Titolo Testata:
Synapse
fascicolo: 4, volume: 19, anno: 1995,
pagine: 264 - 293
SICI:
0887-4476(1995)19:4<264:GDDDBI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; MONOAMINE-DEPLETED MICE; RESERPINE-TREATED MOUSE; EXCITATORY AMINO-ACIDS; SUBTHALAMIC NUCLEUS NEURONS; NMDA RECEPTOR ANTAGONIST; NIGRA PARS RETICULATA; IONTOPHORETICALLY APPLIED DOPAMINE; STRIATONIGRAL PROJECTION NEURONS; NEONATAL 6-OHDA-LESIONED RATS;
Keywords:
DOPAMINE; GLUTAMATE ANTAGONISTS; NMDA; AMPA; D-1 RECEPTORS; D-2 RECEPTORS; PARKINSONS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
278
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Starr, "GLUTAMATE DOPAMINE D-1 D-2 BALANCE IN THE BASAL GANGLIA AND ITS RELEVANCE TO PARKINSONS-DISEASE/", Synapse, 19(4), 1995, pp. 264-293

Abstract

The recent availability of selective ligands for NMDA and AMPA receptors has enabled neuroscientists to test the hypothesis that Parkinson's disease is a glutamate hyperactivity disorder and hence treatable with glutamate antagonists. This review takes a critical look at the motor characteristics of this new class of drugs in rodent and primate models of parkinsonism and assesses the clinical potential and pitfalls of this radical new approach. Monotherapy of Parkinsons's disease withglutamate antagonists appears impractical at the present time, due totheir low efficacy and unacceptable side effects, but polypharmacy with L-DOPA and a glutamate antagonist as adjuvant is a more realistic prospect. This review will focus on the ways in which glutamate receptor blockade facilitates motor recovery with L-DOPA and will examine whether the basis for this beneficial effect can be traced to a specific interaction with dopamine at D-1 or D-2 receptors, and therefore to discrete motor pathways within the basal ganglia. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:36:33