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Titolo:
EFFECTS OF INTRAPERITONEAL ANTIBIOTICS ON HUMAN PERITONEAL MESOTHELIAL CELL-GROWTH
Autore:
YEN CJ; TSAI TJ; CHEN HS; FANG CC; YANG CC; LEE PH; LIN RH; TSAI KS; HUNG KY; YEN TS;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT EMERGENCY MED,7,CHUNG SHAN S RD TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,DEPT EMERGENCY MED TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,DEPT SURG TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,LAB MED TAIPEI TAIWAN NATL TAIWAN UNIV,GRAD INST IMMUNOL TAIPEI 10764 TAIWAN
Titolo Testata:
Nephron
fascicolo: 4, volume: 74, anno: 1996,
pagine: 694 - 700
SICI:
0028-2766(1996)74:4<694:EOIAOH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS; INVITRO; CULTURE; AGENTS;
Keywords:
HUMAN PERITONEAL MESOTHELIAL CELL; CAPD PERITONITIS; INTRAPERITONEAL ANTIBIOTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Yen et al., "EFFECTS OF INTRAPERITONEAL ANTIBIOTICS ON HUMAN PERITONEAL MESOTHELIAL CELL-GROWTH", Nephron, 74(4), 1996, pp. 694-700

Abstract

Peritonitis is one of the most frequent complications of continuous ambulatory peritoneal dialysis (CAPD). Necrosis and exfoliation of the mesothelial cell layer of the peritoneum develop during the acute phase of peritonitis. Agents that hamper regeneration of mesothelial cellswill cause delayed recovery of the peritoneal surface, which results in continuous exposure of underlying stem cells to the stimulation of growth factors and possibly leads to peritoneal fibrosis syndrome. Theaim of the present study is to determine the effects of several intraperitoneal antibiotics on human peritoneal mesothelial cell (HPMC) growth at their usual loading and maintenance doses. HPMCs were isolated from human omenta. Proliferation of HPMC was evaluated by modified methyltetrazolium assay and cell membrane integrity was assessed by lactate dehydrogenase method. The results showed that most cephalosporins exert an inhibitory, even toxic, effect on HPMCs at their loading doses. Cephalothin, cephradine, cefamandole, cefoxitin, cefuroxime and cefoperazone inhibited HPMC proliferation at their maintenance doses. Vancomycin, clindamycin, aztreonam, piperacillin, imipenem, tobramycin andceftriaxone have no effect in their usual intraperitoneal doses. Fromthe viewpoint of peritoneal protection, not only drug sensitivity of the causative microorganisms but also effects of antibiotics on HPMC regeneration should be considered when selecting antibiotics for CAPD peritonitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:07:16