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Titolo:
ESTROGEN-RECEPTOR OCCURRENCE IN THE FEMALE MOUSE-BRAIN - EFFECTS OF MATERNAL EXPERIENCE, OVARIECTOMY, ESTROGEN AND ANOSMIA
Autore:
EHRET G; BUCKENMAIER J;
Indirizzi:
UNIV ULM,VERGLEICHENDE NEUROBIOL ABT D-89069 ULM GERMANY
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 5, volume: 88, anno: 1994,
pagine: 315 - 329
SICI:
0928-4257(1994)88:5<315:EOITFM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; MONOCLONAL-ANTIBODIES; IMMUNOREACTIVE CELLS; PARENTAL EXPERIENCE; PREOPTIC AREA; HOUSE MICE; ULTRASOUND RECOGNITION; OLFACTORY EPITHELIUM; OXYTOCIN RECEPTORS; VOMERONASAL ORGAN;
Keywords:
ESTROGEN RECEPTOR; MATERNAL EXPERIENCE; OLFACTORY LEARNING; LIMBIC SYSTEM; PARENTAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
G. Ehret e J. Buckenmaier, "ESTROGEN-RECEPTOR OCCURRENCE IN THE FEMALE MOUSE-BRAIN - EFFECTS OF MATERNAL EXPERIENCE, OVARIECTOMY, ESTROGEN AND ANOSMIA", J PHYSL-PAR, 88(5), 1994, pp. 315-329

Abstract

Maternal behavior (ultrasound-induced pup-searching and retrieving) was studied in eight groups of female house mice with various hormonal backgrounds, experience with pups and function of the olfactory system. In their brains, estrogen receptor immunoreactive (ER-IR) cells werelocalized and quantified. All animals of all groups had ER-IR cells in a 'reliable subset' of brain areas, the medial preoptic area (MPOA) and ventromedial (VMH) and arcuate nucleus (ARH) of the hypothalamus. In another subset of brain areas, the anterior hypothalamic area (AHA)and cortical (CA) and medial (MA) amygdaloid nucleus, ER-IR cells canbe expected in at least some animals of all experimental groups ('expected subset'). In a variable subset of additional brain areas (bed nucleus of the stria terminalis, BNST; suprachiasmatic nucleus, SC; lateral septal nuclei, LS; paraventricular nucleus of the hypothalamus, PVH; entorhinal and piriform cortex, ENT, PIR; subiculum, SUB; hippocampus, HPC; periventricular gray of the midbrain, PVG), ER-IR cells occurred only in some animals of some groups. Numbers of ER-IR cells in a given brain area, volumes occupied by these cells, and cell densities varied considerably among the groups. A covariation of cell counts and volumes was significant for most brain areas indicating that increasesof numbers of ER-IR cells relate mainly to volume increases within a given brain area. Experience with pups correlated with an increase of ER presence in the AHA, VMH, ENT, PIR, SUB, HPC and PVG, however, onlyin the presence of estrogen. Estrogen and pup-experience together ledto an increased ER presence in mainly the VMH, ENT and PIR, however, only in females with intact olfaction. Full maternal behavior (retrieving, ultrasound recognition) occurred after the high pregnancy- or experience-induced ER content was reduced to lower levels. The ER occurrence in lactating and experienced virgin females differed, however, in the AHA, BNST, SC, PVH, ENT, PIR, SUB, HPC and PVG showing that the maintenance of maternal behavior can run under different profiles of ER content in the brain. Ovariectomy and/or prolonged high blood-estrogenlevels correlated significantly with decreased levels of ER-IR cells in most brain areas which could not be increased by pup-experience.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 17:40:35