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Titolo:
MICELLAR LIQUID-CHROMATOGRAPHIC SEPARATION OF SULFONAMIDES IN PHYSIOLOGICAL SAMPLES USING DIRECT ON-COLUMN INJECTION
Autore:
YANG SY; KHALEDI MG;
Indirizzi:
N CAROLINA STATE UNIV,DEPT CHEM,POB 8204 RALEIGH NC 27695 N CAROLINA STATE UNIV,DEPT CHEM RALEIGH NC 27695
Titolo Testata:
Journal of chromatography
fascicolo: 1-2, volume: 692, anno: 1995,
pagine: 311 - 318
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIRECT SERUM INJECTION; MOBILE PHASE; OPTIMIZATION; SELECTIVITY; STRENGTH; DRUGS; HPLC; MILK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S.Y. Yang e M.G. Khaledi, "MICELLAR LIQUID-CHROMATOGRAPHIC SEPARATION OF SULFONAMIDES IN PHYSIOLOGICAL SAMPLES USING DIRECT ON-COLUMN INJECTION", Journal of chromatography, 692(1-2), 1995, pp. 311-318

Abstract

A mixture of twelve sulfonamides was separated by micellar liquid chromatography (MLC) using sodium dodecyl sulfate (SDS) micelles and a hydrophilic endcapped C-18 column. Retention behavior and selectivity pattern of sulfonamides in MLC were examined with the change of SDS concentration and volume fraction of an organic modifier (1-propanol). Thesuitable condition was found to be 0.070 M SDS and 6.0% 1-propanol for the separation of these twelve sulfonamides. Under this condition, the isocratic separation of the sulfonamides was achieved within 15 minwith a relatively high column efficiency for MLC (ca. 7000 plates/25 cm column). Retention times of these twelve sulfonamides were found tobe very repeatable, which is due to the highly reproducible retentionbehavior in MLC. The same twelve sulfonamides were successfully separated in the spiked physiological fluids (human urine and cow milk) through direct on-column injection by MLC.

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Documento generato il 07/04/20 alle ore 03:57:12