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Titolo:
AMPHETAMINE-INDUCED AND COCAINE-INDUCED FOS IN THE RAT STRIATUM DEPENDS ON D-2 DOPAMINE-RECEPTOR ACTIVATION
Autore:
RUSKIN DN; MARSHALL JF;
Indirizzi:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL IRVINE CA 92717
Titolo Testata:
Synapse
fascicolo: 3, volume: 18, anno: 1994,
pagine: 233 - 240
SICI:
0887-4476(1994)18:3<233:AACFIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR GENES; IMMEDIATE-EARLY GENES; D1/D2 SYNERGISM; STRIATOPALLIDAL NEURONS; SUBSTITUTED BENZAMIDE; ROTATIONAL BEHAVIOR; CIRCLING BEHAVIOR; SUBSTANTIA-NIGRA; H-3 ETICLOPRIDE; D2 RECEPTORS;
Keywords:
IMMEDIATE-EARLY GENE; D-1/D-2 SYNERGISM; ETICLOPRIDE; STRIATONIGRAL NEURONS; FLUOROGOLD; RETROGRADE TRACER; IMMUNOFLUORESCENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D.N. Ruskin e J.F. Marshall, "AMPHETAMINE-INDUCED AND COCAINE-INDUCED FOS IN THE RAT STRIATUM DEPENDS ON D-2 DOPAMINE-RECEPTOR ACTIVATION", Synapse, 18(3), 1994, pp. 233-240

Abstract

Amphetamine or cocaine injection causes expression of the immediate-early gene c-fos in the striatum. Previous studies have shown that dopamine D-1 receptor activation is necessary for this effect, but have not established a consistent role for D-2 receptors. We have investigated the involvement of D-2 receptors in indirect dopamine agonist-induced striatal Fos-like immunoreactivity using the selective D-2 antagonist eticlopride. Eticlopride treatment (0.5 mg/kg) caused Fos expressionby itself, but also decreased Fos expression in the central striatum due to amphetamine (5.0 mg/kg) or cocaine (40 mg/kg) by 90% and 85%, respectively. In striatonigral neurons, identified by labeling with theretrograde tracer Fluorogold iontophoresed into the substantia nigra pars reticulata, the blockade of stimulant-induced Fos-like immunofluorescence by eticlopride was nearly complete, with decreases of 98% foramphetamine and 94% for cocaine. In striatonigral neurons, the D-2 antagonist alone had minimal effect. We conclude that activation of bothD-1 and D-2 receptor classes by dopamine agonists is necessary for induction of Fos in the striatonigral cells of normal rats. These results provide an important parallel to behavioral and electrophysiologicalwork that also demonstrates D-1/D-2 interdependence in the control ofnormal basal ganglia functions. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:01