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Titolo:
COMPLEXES OF GA3-BIS(BUTYLAMIDE) DERIVATIVE OF DIETHYLENETRIAMINEPENTAACETIC ACID - STABILITY-CONSTANTS AND NUCLEAR-MAGNETIC-RESONANCE STUDIES IN AQUEOUS-SOLUTION( AND IN3+ WITH THE N,N'')
Autore:
GERALDES CFGC; DELGADO R; URBANO AM; COSTA J; JASANADA F; NEPVEU F;
Indirizzi:
UNIV TOULOUSE 3,CIBLAGE THERAPEUT LAB F-31062 TOULOUSE FRANCE UNIV COIMBRA,DEPT BIOCHEM P-3000 COIMBRA PORTUGAL INST SUPER TECN,CTR QUIM ESTRUTURAL P-1096 LISBON PORTUGAL
Titolo Testata:
Journal of the Chemical Society. Dalton transactions
fascicolo: 3, , anno: 1995,
pagine: 327 - 335
SICI:
0300-9246(1995):3<327:COGDOD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIFUNCTIONAL CHELATING-AGENTS; GADOLINIUM-LABELED LIPOSOMES; METAL-ION COMPLEXES; LANTHANIDE(III) COMPLEXES; CONTRAST AGENTS; DTPA; LIGANDS; NMR; MULTINUCLEAR; THERMODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
C.F.G.C. Geraldes et al., "COMPLEXES OF GA3-BIS(BUTYLAMIDE) DERIVATIVE OF DIETHYLENETRIAMINEPENTAACETIC ACID - STABILITY-CONSTANTS AND NUCLEAR-MAGNETIC-RESONANCE STUDIES IN AQUEOUS-SOLUTION( AND IN3+ WITH THE N,N'')", Journal of the Chemical Society. Dalton transactions, (3), 1995, pp. 327-335

Abstract

Potentiometric titrations showed that the sum of the first three protonation constants of diethylenetriaminepentaacetate N,N''-bis(butylamide) (L(1)) decreases by 6.6 units when compared to the diethylenetriaminepentaacetate (dtpa). and that the complexes of Ga3+ and In3+ of L(1) have stability constants 6.1-6.3 log units lower than those of dtpa. The decreased basicity of the bis(amide) derivative thus correlates with the lower stability of its complexes. However. at pH 7.4 the loweroverall basicity of L(1) compared to dtpa partly compensates the lower stability of its complexes, thus causing their conditional stabilityconstants to be comparable to those of the dtpa complexes. The efficacy of L(1) in binding Ga3+ and In3+ under physiological conditions is discussed by comparing pM values at pH 7.4, showing that this compoundcan withstand the competition of transferrin for In3+ in biological media relevant to medical applications. The C-13 and H-1 NMR shifts were measured for the complexes of Al3+. Ga3+, In3+ and Y3+ with L(1) andcompared with C-13 shifts for the dtpa complexes. The complexes of AP(+) and Ga3+ are hexadentate, possibly of octahedral geometry, and form various structural isomers, whereas those of ln(3+) and Y3+, With a single structural isomer of eight-co-ordination, are very similar to the lanthanide complexes. The complexes of Al3+ and Ga3+ of L(1) have considerable populations of isomers with bound amide groups, whereas the single structural isomer of the complexes of In3+ and Y3+ With both amide groups co-ordinated yield a variety of enantiomers in solution.

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Documento generato il 02/12/20 alle ore 04:39:20