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Titolo:
THE MORPHOLOGY OF THROMBIN-ACTIVATED PLATELETS WITH REFERENCE TO DIFFERENT FIBRINOGEN CONCENTRATIONS AS REVEALED BY COMPUTER-AIDED 3-DIMENSIONAL RECONSTRUCTION
Autore:
DIERICHS R; SCHMITZNAHRATH M;
Indirizzi:
UNIV MUNSTER,INST ANAT,VESALIUSWEG 2-4 D-48149 MUNSTER GERMANY UNIV MUNSTER,INST ANAT D-48149 MUNSTER GERMANY
Titolo Testata:
Platelets
fascicolo: 1, volume: 6, anno: 1995,
pagine: 31 - 36
SICI:
0953-7104(1995)6:1<31:TMOTPW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-CANALICULAR SYSTEM; RECEPTOR LIGAND COMPLEXES; HUMAN-BLOOD PLATELETS; IIB-IIIA RECEPTOR; ELECTRON-MICROSCOPY; DYNAMIC MEASUREMENTS; FLOW-CYTOMETRY; SURFACE; AGGREGATION; ENDOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R. Dierichs e M. Schmitznahrath, "THE MORPHOLOGY OF THROMBIN-ACTIVATED PLATELETS WITH REFERENCE TO DIFFERENT FIBRINOGEN CONCENTRATIONS AS REVEALED BY COMPUTER-AIDED 3-DIMENSIONAL RECONSTRUCTION", Platelets, 6(1), 1995, pp. 31-36

Abstract

Washed human platelets incubated in different concentrations of fibrinogen were activated by thrombin and aggregated in the presence of Ca2 or did not aggregate when EDTA was present. They were analyzed by transmission electron microscopy and computer-aided three-dimensional reconstruction. The volumes and surface areas of the reconstructed models were calculated. The quotients of the values calculated for the whole platelet and the surface-connected canalicular system were taken as measures of the degree of surface invagination. Increasing the concentrations of fibrinogen reduced the values of the quotients indicating enhanced internalization of surface membranes, and tended to smoothen the outer surfaces to obtain spherical shapes. The invaginations are much more pronounced in platelets that did not aggregate in the presenceof EDTA suggesting that aggregation fixes some membrane areas that otherwise would be redistributed to the platelet's inner compartments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:30:17