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Titolo:
INVESTIGATION OF DISSOLUTION AND BIOEQUIV ALENCE OF SILYMARIN PRODUCTS
Autore:
SCHULZ HU; SCHURER M; KRUMBIEGEL G; WACHTER W; WEYHENMEYER R; SEIDEL G;
Indirizzi:
PROMENADENWEG 10,POSTFACH 1322 D-23602 BAD SCHWARTAU GERMANY LAFAA,CONTRACT RES CLIN PHARMACOL LAB BAD SCHWARTAU GERMANY BIOPHARMACEUT ANALYT GMBH BAD SCHWARTAU GERMANY MADAUS AG COLOGNE GERMANY INFILL KOMMUNIKAT KONIGSWINTER OBERPLEIS GERMANY
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 1, volume: 45-1, anno: 1995,
pagine: 61 - 64
SICI:
0004-4172(1995)45-1:1<61:IODABA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Keywords:
CAS 22888-70-6; LEGALON(R) 140; SILIBININ; SILYMARIN PRODUCTS, BIOEQUIVALENCE, DISSOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
H.U. Schulz et al., "INVESTIGATION OF DISSOLUTION AND BIOEQUIV ALENCE OF SILYMARIN PRODUCTS", Arzneimittel-Forschung, 45-1(1), 1995, pp. 61-64

Abstract

Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin(CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these test three products were checked for bioequivalence. Therefore, a typical phase I 3 fold crossover study was performed showing one product (Legalon(R)) to be qualified by an approx. 2 fold higher silibinin availability compared to the two other preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:33:04