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Titolo:
ADRIAMYCIN-INDUCIBLE PROTEINS ASSOCIATED WITH DRUG-SENSITIVITY IN RESISTANT IMMUNOBLASTIC B-LYMPHOMA-CELLS
Autore:
CHAO CCK; YAM WC; CHUNG KC; HO YS;
Indirizzi:
CHANG GUNG MED COLL,DEPT BIOCHEM,TUMOR BIOL LAB TAYUAN 33332 TAIWAN CHANG GUNG MED COLL,DEPT PATHOL TAYUAN 33332 TAIWAN
Titolo Testata:
Mutation research. Mutation research letters
fascicolo: 1, volume: 346, anno: 1995,
pagine: 33 - 41
SICI:
0165-7992(1995)346:1<33:APAWDI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; RAS ONCOGENE; H-RAS; C-MYC; BURKITTS-LYMPHOMA; EPITHELIAL-CELLS; KINASE-C; EXPRESSION; LINE; ESTABLISHMENT;
Keywords:
DRUG ACCUMULATION; DRUG-INDUCIBLE PROTEIN; DRUG RESISTANCE; IMMUNOBLASTIC B LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C.C.K. Chao et al., "ADRIAMYCIN-INDUCIBLE PROTEINS ASSOCIATED WITH DRUG-SENSITIVITY IN RESISTANT IMMUNOBLASTIC B-LYMPHOMA-CELLS", Mutation research. Mutation research letters, 346(1), 1995, pp. 33-41

Abstract

We have previously established an immunoblastic B lymphoma cell line,designated HOB1. This cell line is hypersensitive to a wide spectrum of chemotherapeutic agents. Two co-regulated polypeptides around 64 kDa (termed p64) were induced 10-30-fold in response to adriamycin and some other drugs at the IC50 (the concentration inhibiting cell growth by 50%). These inducible proteins are localized as monomeric forms in the cytosolic fraction, with isoelectric points of pH = 6.2 (major protein) and pH = 7.0 (minor protein). An adriamycin-resistant cell line was established from HOB1 cells. The p64 inducibility was dramaticallyreduced in resistant HOB1 cells or unrelated cell lines which show phenotypic resistance to adriamycin toxicity. The loss of p64 inducibility in resistant cells is not due to a failure of cells to take up adriamycin since drug accumulation kinetics remained the same as in the parental cells.

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Documento generato il 07/07/20 alle ore 05:31:38