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Titolo:
EFFECT OF CLOSTRIDIUM-PERFRINGENS DERIVED WOUND-HEALING SUBSTANCE AS COMPARED WITH EPIDERMAL GROWTH-FACTOR ON THE GROWTH AND MORPHOLOGICAL TRANSFORMATION OF BALB 3T3 A31-1-1 CELLS/
Autore:
ARIMA T; TADA S; MAKITA Y; KURONO M; UMEDA M;
Indirizzi:
SANWA KAGAKU KENKYUSHO CO LTD,MIE RES LAB,SHIOSAKI 363 HOKUSEI MIE 51104 JAPAN YOKOHAMA CITY UNIV,KIHARA INST BIOL RES,MINAMI KU YOKOHAMA KANAGAWA 232 JAPAN
Titolo Testata:
Mutation research. Genetic toxicology testing
fascicolo: 3, volume: 341, anno: 1995,
pagine: 217 - 224
SICI:
0165-1218(1995)341:3<217:EOCDWS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR PROMOTERS; 3T3 CELLS; ENHANCEMENT; RADIATION; INDUCTION; MICE;
Keywords:
CLOSTRIDIUM PERFRINGENS-DERIVED WOUND HEALING SUBSTANCE (WHS); SNK-863; BALB/3T3 CELL TRANSFORMATION; DOUBLING TIME; TUMOR INITIATION; TUMOR PROMOTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Arima et al., "EFFECT OF CLOSTRIDIUM-PERFRINGENS DERIVED WOUND-HEALING SUBSTANCE AS COMPARED WITH EPIDERMAL GROWTH-FACTOR ON THE GROWTH AND MORPHOLOGICAL TRANSFORMATION OF BALB 3T3 A31-1-1 CELLS/", Mutation research. Genetic toxicology testing, 341(3), 1995, pp. 217-224

Abstract

Clostridium perfringens-derived wound-healing substance (WHS), havinggrowth-stimulating activity, was examined to determine its effect on the growth and morphological transformation of BALB/3T3 A31-1-1 cells. WHS accelerated the cell growth at the exponential growth phase, shortening the doubling time by 8-18%. The maximum cell density of the treated cultures was slightly higher than that of the control culture, and the cell number decreased in the same way as the control cells did. On the other hand, the cells treated with epidermal growth factor (EGF) or insulin showed growth rates similar to that of the control cells during the exponential growth phase, and after the control cells attained the maximum cell number, the number of the treated cells continuedto increase gradually for more than 4 days and then decreased. Under the experimental conditions of the two-stage transformation assay, application of WHS at the tumor-initiation or promotion stage did not accelerate the formation of transformed foci. Although treatment with EGFat the initiation stage induced no enhancement, marked enhancement ofmorphological transformation was observed in the treatment at the promotion stage. These results indicate that the mode of action between WHS and EGF or insulin is different on the growth-stimulating activity and morphological transformation of BALB/3T3 A31-1-1 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:19:45