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Titolo:
CEREBRAL AUTOREGULATION DYNAMICS IN PREMATURE NEWBORNS
Autore:
PANERAI RB; KELSALL AWR; RENNIE JM; EVANS DH;
Indirizzi:
LEICESTER ROYAL INFIRM,DEPT MED PHYS LEICESTER LE1 5WW LEICS ENGLAND UNIV LEICESTER,FAC MED,DIV MED PHYS LEICESTER LEICS ENGLAND ROSIE MATERN HOSP,NEONATAL UNIT CAMBRIDGE ENGLAND
Titolo Testata:
Stroke
fascicolo: 1, volume: 26, anno: 1995,
pagine: 74 - 80
SICI:
0039-2499(1995)26:1<74:CADIPN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; PULSED DOPPLER ULTRASOUND; PRETERM INFANTS; AUTO-REGULATION; INTRAVENTRICULAR HEMORRHAGE; PRESSURE; VARIABILITY; RESPONSES; FAILURE;
Keywords:
AUTOREGULATION; CEREBRAL BLOOD FLOW; INFANTS; MIDDLE CEREBRAL ARTERY; ULTRASONICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Panerai et al., "CEREBRAL AUTOREGULATION DYNAMICS IN PREMATURE NEWBORNS", Stroke, 26(1), 1995, pp. 74-80

Abstract

Background and Purpose Autoregulation of cerebral blood flow is easily disrupted, and loss of this normal physiological reflex may worsen the neurological outcome for patients undergoing intensive care. We studied the response of cerebral blood flow velocity to changes in mean arterial blood pressure. Methods Cerebral blood flow velocity was measured with Doppler ultrasonography in one middle cerebral artery for 5-minute periods in 33 babies of gestational age <33 weeks admitted to a neonatal intensive care unit. Two methods of evaluating autoregulationwere developed. The first used linear regression analysis of blood flow velocity on blood pressure. Records were classified as showing lossof autoregulation if the regression slope was greater than a criticalvalue. A minimum change in mean arterial blood pressure of 5 mm Hg and a critical slope of 1.5 %/mm Hg were found to be adequate criteria for the classification of records by the regression method. The second method used coherent averaging, a technique similar to that used in recording evoked potentials. Spontaneous transient increases in blood pressure were automatically detected, and the instant corresponding to its maximum rate of rise was used to synchronize averages of the blood pressure and blood velocity transients. The resulting coherent averages were classified into two groups based on the morphology of the cerebral blood flow velocity average. Results Whereas the regression methodallowed the classification of only 51 of 106 records, the coherent average method classified 101 of 106 (95.3%) of the records available. For 51 records that were classified by both methods, there was agreement in 42 cases (82.3%). The coherent average of all records classified as having an active autoregulation showed cerebral blood flow velocityreturning to baseline much earlier than blood pressure, suggesting that autoregulation was taking place within 1 to 2 seconds. This patternwas absent in records in which autoregulation was classified as absent. Conclusions Computerized coherent averaging of the cerebral blood how velocity response to spontaneous blood pressure transients offers apromising new method for noninvasive bedside assessment of autoregulation in patients undergoing intensive care. The time course for autoregulation, when present, is in agreement with that reported in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:51:08