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Titolo:
PROSTACYCLIN AND ITS ANALOGS - ANTIMETASTATIC EFFECTS AND MECHANISMS OF ACTION
Autore:
SCHNEIDER MR; TANG DG; SCHIRNER M; HONN KV;
Indirizzi:
WAYNE STATE UNIV,DEPT CANC BIOL,431 CHEM DETROIT MI 48201 WAYNE STATE UNIV,DEPT RADIAT ONCOL DETROIT MI 48202 WAYNE STATE UNIV,DEPT CHEM DETROIT MI 48202 WAYNE STATE UNIV,DEPT PATHOL DETROIT MI 48202 SCHERING AG,RES LABS D-13342 BERLIN GERMANY HARPER GRACE HOSP,GERSHENSON RADIAT ONCOL CTR DETROIT MI 48201
Titolo Testata:
Cancer metastasis reviews
fascicolo: 3-4, volume: 13, anno: 1994,
pagine: 349 - 364
SICI:
0167-7659(1994)13:3-4<349:PAIA-A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-CELL ADHESION; INDUCED PLATELET-AGGREGATION; ENDOTHELIAL-CELLS; ALPHA-V-BETA-3 INTEGRINS; EXPERIMENTAL METASTASIS; SUBENDOTHELIAL MATRIX; EXTRACELLULAR-MATRIX; NUDE-MOUSE; INHIBITION; ENHANCEMENT;
Keywords:
PROSTACYCLIN; METASTASIS; CICAPROST; PLATELET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Schneider et al., "PROSTACYCLIN AND ITS ANALOGS - ANTIMETASTATIC EFFECTS AND MECHANISMS OF ACTION", Cancer metastasis reviews, 13(3-4), 1994, pp. 349-364

Abstract

More than a decade ago, prostacyclin, a dienoic bicyclic eicosanoid derived from the metabolism of arachidnoic acid, was found to possess potent inhibitory effects on tumor cell metastasis. Thereafter, severallaboratories demonstrated the metastasis-suppressive activity of prostacyclin in a wide spectrum of tumor types. Due to the short half-lifeof prostacyclin, researchers have focused on looking for stable prostacyclin analogues which have extended half lives and increased bioavailabilities. Cicaprost, among other prostacyclin analogues tested, has been demonstrated, like prostacyclin, to effectively inhibit metastasis in several different animal models (i.e., both experimental and spontaneous metastasis models). Prostacyclin as well as cicaprost prevent not only hematogenous, but also lymphatic metastasis. Furthermore, these compounds also inhibit the growth of established micrometastases after removal of the primary tumors. Mechanistic studies revealed that the antimetastatic effects of prostacyclin and its analogues are more related to their interference with tumor cell-host interactions (such as tumor cell induced platelet aggregation, tumor cell adhesion to endothelial cells and subendothelial matrix, tumor cell induced endothelial cell retraction, etc.) than their direct inhibition of the growth ofprimary tumors. The potent and widespread metastasis-retarding effects of prostacyclin and its stable analogues in animal tumor models warrant their clinical trial in treating human cancer patients and preventing metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:27:40