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Titolo:
DEVELOPMENTAL CONTROL OF CELL-CYCLE REGULATORS - A FLYS PERSPECTIVE
Autore:
EDGAR BA; LEHNER CF;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,DIV BASIC SCI,1124 COLUMBIA ST SEATTLE WA 98109 UNIV BAYREUTH,DEPT GENET D-95440 BAYREUTH GERMANY
Titolo Testata:
Science
fascicolo: 5293, volume: 274, anno: 1996,
pagine: 1646 - 1652
SICI:
0036-8075(1996)274:5293<1646:DCOCR->2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; DROSOPHILA WING DISC; IMAGINAL LEG DISKS; S-PHASE; LIMB DEVELOPMENT; PROTEIN-KINASE; MOUSE GENOME; PATTERN REGULATION; METAPHASE ARREST; DNA-REPLICATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
154
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Edgar e C.F. Lehner, "DEVELOPMENTAL CONTROL OF CELL-CYCLE REGULATORS - A FLYS PERSPECTIVE", Science, 274(5293), 1996, pp. 1646-1652

Abstract

During early development in many species, maternally supplied gene products permit the cell cycle to run at maximum velocity, subdividing the fertilized egg into smaller and smaller cells. As development proceeds, zygotic controls are activated that first limit divisions to defined spatial and temporal domains, coordinating them with morphogenesis, and then halt proliferation altogether, to allow cell differentiation. Analysis of the regulation of cyclin-dependent kinases (Cdks) in Drosophila has provided insights into how this embryonic program of cellproliferation is controlled at the molecular level and how it is linked to developmental cues. Recent studies have also begun to reveal howcell proliferation is controlled during the second phase of Drosophila development, which occurs in imaginal tissues. In contrast to their embryonic progenitors, imaginal cells proliferate with a cycle that requires cell growth and is linked to patterning processes controlled bysecreted cell signaling molecules. The functions of these signaling molecules appear to be nearly as conserved between vertebrates and invertebrates as the cell cycle control apparatus itself, suggesting that the mechanisms that coordinate growth, patterning, and cell proliferation in developing tissues have ancient origins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:09:03