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Titolo:
STUDIES ON AGENTS WITH VASODILATOR AND BETA-BLOCKING ACTIVITIES .4.
Autore:
SEKI T; NAKAO T; MASUDA T; HASUMI K; GOTANDA K; ISHIMORI T; HONMA S; MINAMI N; SHIBATA K; YASUDA K;
Indirizzi:
TEIKOKU HORMONE MFG CO LTD,DIV RES,TAKATSU KU,1604 SHIMOSAKUNOBE KAWASAKI KANAGAWA 213 JAPAN
Titolo Testata:
Chemical and Pharmaceutical Bulletin
fascicolo: 11, volume: 44, anno: 1996,
pagine: 2061 - 2069
SICI:
0009-2363(1996)44:11<2061:SOAWVA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE INOTROPIC AGENTS; ACYL ANION EQUIVALENTS; DILATED CARDIOMYOPATHY; CARDIOTONIC AGENTS; DOUBLE-BLIND; 6-)4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES; 1,4-ADDITIONS; PROPRANOLOL; METOPROLOL; BLOCKADE;
Keywords:
PHENOXYPROPANOLAMINE; PYRIDAZINONE; HYPOTENSIVE ACTIVITY; BETA-BLOCKING ACTIVITY; CONGESTIVE HEART FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Seki et al., "STUDIES ON AGENTS WITH VASODILATOR AND BETA-BLOCKING ACTIVITIES .4.", Chemical and Pharmaceutical Bulletin, 44(11), 1996, pp. 2061-2069

Abstract

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and beta-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected forfurther studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:13:39