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Titolo:
ARTERIAL REMODELING - RELATION TO HEMODYNAMICS
Autore:
LANGILLE BL;
Indirizzi:
TORONTO HOSP,RES INST,BANTING & BEST DIABET CTR,200 ELIZABETH ST TORONTO ON M5G 2C4 CANADA UNIV TORONTO,DEPT PATHOL TORONTO ON M5S 1A1 CANADA
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 7, volume: 74, anno: 1996,
pagine: 834 - 841
SICI:
0008-4212(1996)74:7<834:AR-RTH>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; HUMAN ENDOTHELIAL-CELLS; SMOOTH-MUSCLE CELLS; MESSENGER-RNA LEVELS; FLUID SHEAR-STRESS; PROTEIN-KINASE-C; BLOOD-FLOW; GENE CED-3; IL-1-BETA-CONVERTING ENZYME; EXTRACELLULAR-MATRIX;
Keywords:
ARTERIAL REMODELING; SHEAR STRESS; ELASTIN; APOPTOSIS; WALL TENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Langille, "ARTERIAL REMODELING - RELATION TO HEMODYNAMICS", Canadian journal of physiology and pharmacology, 74(7), 1996, pp. 834-841

Abstract

The structure of the artery wall is exquisitely sensitive to the hemodynamic forces imposed on it by blood pressure and blood flow. This sensitivity regulates growth and remodeling of arteries during development, and it regulates long-term adaptive restructuring of mature vessels. Since many vascular pathologies involve alterations in hemodynamic loads, the sensitivity of arterial structure to these changes inevitably affects the progression of vascular diseases. The processes involved in arterial remodeling involve regulation of vascular cell migrationand mitosis and apoptosis rates, control of matrix synthesis and degradation, and regulation of matrix reorganization. Some exciting data have been presented concerning how vascular cells sense mechanical forces, including mechanisms based on shear-sensitive ion channels, control of mass transport of agonists to endothelium by shear strain rate, and modulation of tyrosine phosphorylation of proteins at focal adhesion sites; however, the physiological importance of these mechanisms remains to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:27:15