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Titolo:
SEXUAL DIFFERENCES IN BONE MARKERS AND BONE-MINERAL DENSITY OF NORMALCHINESE
Autore:
TSAI KS; PAN WH; HSU SHJ; CHENG WC; CHEN CK; CHIENG PU; YANG RS; TWU ST;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT LAB MED,7 CHUNG SHAN S RD TAIPEI 100 TAIWAN ACAD SINICA,INST BIOMED SCI TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT RADIOL TAIPEI TAIWAN NATL TAIWAN UNIV,DEPT ORTHOPED TAIPEI TAIWAN NATL TAIWAN UNIV,COLL PUBL HLTH,INST EPIDEMIOL TAIPEI TAIWAN
Titolo Testata:
Calcified tissue international
fascicolo: 6, volume: 59, anno: 1996,
pagine: 454 - 460
SICI:
0171-967X(1996)59:6<454:SDIBMA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE; TRABECULAR BONE; GLA-PROTEIN; BIOCHEMICAL MARKERS; POST-MENOPAUSAL; SERUM; AGE; DISEASE; WOMEN; MEN;
Keywords:
OSTEOCALCIN; PROCOLLAGEN-I C TERMINAL PEPTIDE; BONE ALKALINE PHOSPHATASE; N-TELEOPEPTIDE TYPE I COLLAGEN; BONE MINERAL DENSITY; CHINESE MEN AND WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Tsai et al., "SEXUAL DIFFERENCES IN BONE MARKERS AND BONE-MINERAL DENSITY OF NORMALCHINESE", Calcified tissue international, 59(6), 1996, pp. 454-460

Abstract

We measured bone mineral density (BMD) at lumbar (L2-L4) vertebrae and proximal femurs of 385 healthy Chinese women aged 40-70 years and 156 healthy Chinese men aged 20-85, and four markers-bone alkaline phosphatase isozyme (BAP), procollagen-I C terminal propeptide (PICP), osteocalcin (BGP) in serum, and a bone resorption marker, urinary cross-linked N-telopeptide of type I collagen (NTX), of these subjects. The results indicate that in postmenopausal women, levels of all the markersincreased with age. In men, serum BAP, PICP, and urinary NTX decreased significantly, and serum BGP decreased with borderline significance (P = 0.08). With increasing age, bone density decreased at both sites in postmenopausal women and at the proximal femur in men. The lumbar bone density showed no significant age-related changes in men. In premenopausal women, BMD at either site showed no significant change with increasing age. Despite the different trends between men and women of age-related changes in BMD and bone markers, bone density of both proximal femur and spine in both sexes correlated inversely with levels of the bone markers in a manner independent of age or body weight. The meaning of opposite age effects on bone markers in men and women needs further investigation. In addition, higher bone marker levels, implyingfaster bone turnover rate, are associated with lower BMD in both sexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:21:39