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Titolo:
EFFECT OF ETHAMBUTOL ON EMERGENCE OF CLARITHROMYCIN-RESISTANT MYCOBACTERIUM-AVIUM COMPLEX IN THE BEIGE MOUSE MODEL
Autore:
BERMUDEZ LE; NASH KA; PETROFSKY M; YOUNG LS; INDERLIED CB;
Indirizzi:
CALIF PACIFIC MED CTR,RES INST,KUZELL INST ARTHRIT & INFECT DIS,2200 WEBSTER ST,SUITE 305 SAN FRANCISCO CA 94115 CHILDRENS HOSP,DEPT PATHOL & LAB MED LOS ANGELES CA 00000 UNIV SO CALIF LOS ANGELES CA 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 174, anno: 1996,
pagine: 1218 - 1222
SICI:
0022-1899(1996)174:6<1218:EOEOEO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION; INTRACELLULARE; AZITHROMYCIN; THERAPY; DISEASE; MICE; SELECTION; INVITRO; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "EFFECT OF ETHAMBUTOL ON EMERGENCE OF CLARITHROMYCIN-RESISTANT MYCOBACTERIUM-AVIUM COMPLEX IN THE BEIGE MOUSE MODEL", The Journal of infectious diseases, 174(6), 1996, pp. 1218-1222

Abstract

An animal model was developed for studying macrolide-resistant Mycobacterium avium complex (MAC) and to measure the effect of ethambutol onresistance, MAC-infected beige mice were given clarithromycin daily; the frequency of clarithromycin-resistant MAC after 8 and 12 weeks was10(-3) and 10(-2), respectively. Combined ethambutol plus clarithromycin did not increase anti-MAC activity, but clarithromycin-resistant MAC was less frequent (P < .05), The frequency of clarithromycin-resistant MAC in mice receiving the combination was significantly higher than that in untreated mice, These results are consistent with two human trials, which showed that adding ethambutol reduced the frequency of clarithromycin-resistant MAC. Results of the present study suggest thatwith an initially high level of MAC infection, the addition of ethambutol may only delay resistance, This mouse test system will be useful for investigating the influence of the level of MAC infection and the effect of other drugs on the frequency of resistant MAC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:15:34