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Titolo:
INTERLEUKIN-2 IS INDISPENSABLE FOR DEVELOPMENT OF IMMUNOLOGICAL SELF-TOLERANCE
Autore:
KLEBB G; AUTENRIETH IB; HABER H; GILLERT E; SADLACK B; SMITH KA; HORAK I;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERSBACHER STR 7 D-8700 WURZBURGGERMANY UNIV WURZBURG,INST HYG & MICROBIOL D-8700 WURZBURG GERMANY CORNELL UNIV,MED CTR,DIV ALLERGY & IMMUNOL NEW YORK NY 10021 RES INST MOL PHARMACOL,DEPT MOL GENET D-12207 BERLIN GERMANY
Titolo Testata:
Clinical immunology and immunopathology
fascicolo: 3, volume: 81, anno: 1996,
pagine: 282 - 286
SICI:
0090-1229(1996)81:3<282:IIIFDO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; AUTOIMMUNITY; DISEASE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
G. Klebb et al., "INTERLEUKIN-2 IS INDISPENSABLE FOR DEVELOPMENT OF IMMUNOLOGICAL SELF-TOLERANCE", Clinical immunology and immunopathology, 81(3), 1996, pp. 282-286

Abstract

Interleukin-2-deficient mice (IL-2(-/-)) manifest severe immune system abnormalities characterized by an uncontrolled activation and proliferation of lymphocytes. A systemic autoimmune syndrome results, and hemolytic anemia leads to early death especially in mice derived from a BALB/c genotype. Remarkably, IL-2 treatment prevents both the activation of the immune system and the development of autoimmune disease. Moreover, adoptive transfer of lymphocytes from IL-2-treated IL-2(-/-) animals confers protection to IL-2(-/-) mice, suggesting that IL-2 induces a postnatal differentiation/maturation of regulatory cells necessary for self- and non-self-discrimination. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:51:46