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Titolo:
VOLTAGE-GATED CURRENTS IN IDENTIFIED PARASYMPATHETIC CARDIAC NEURONS IN THE NUCLEUS AMBIGUUS
Autore:
MIHALEVICH M; NEFF RA; MENDELOWITZ D;
Indirizzi:
UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS,894 UNION AVE MEMPHIS TN 38163 UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS MEMPHIS TN 38163
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 739, anno: 1996,
pagine: 258 - 262
SICI:
0006-8993(1996)739:1-2<258:VCIIPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT SODIUM-CHANNELS; ROOT GANGLION NEURONS; RAT; HEART; BAROREFLEX; TRANSPORT;
Keywords:
VAGAL; HEART; CARDIOVASCULAR; A CURRENT; TETRODOTOXIN; 4-AMINOPYRIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Mihalevich et al., "VOLTAGE-GATED CURRENTS IN IDENTIFIED PARASYMPATHETIC CARDIAC NEURONS IN THE NUCLEUS AMBIGUUS", Brain research, 739(1-2), 1996, pp. 258-262

Abstract

Heart rate is normally dominated by the activity of the cardioinhibitory parasympathetic nervous system, while abnormally low levels of parasympathetic cardiac activity have been implicated in many cardiovascular diseases including hypertension, heart failure and sudden cardiac death. In this study we have examined the voltage-gated currents in parasympathetic cardiac neurons that were identified with a retrograde fluorescent tracer in visualized sections (250 mu m) of nucleus ambiguus. Depolarization of parasympathetic cardiac neurons to potentials more positive than -50 mV evoked a rapidly activating and inactivating inward current which could be blocked by tetrodotoxin (TTX), although insome neurons up to 10 mu M was required for complete block, The voltage-dependent inactivation properties of this Na current showed relatively broad inactivation characteristics, a characteristic of TTS-resistant Na channels, Depolarization also elicited biphasic outward currents, which were separated into a transient I-A type K current using the specific channel antagonist 4-aminopyridine and a long-lasting delayedrectified K current. These voltage-gated Na and K currents define theaction potential firing patterns of parasympathetic cardiac neurons, such as frequency adaptation and spike delay, and also determine the activity of these neurons in response to depolarizing and hyperpolarizing synaptic innervation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:37:16