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Titolo:
BRAIN MONOAMINE-OXIDASE-A INHIBITION IN CIGARETTE SMOKERS
Autore:
FOWLER JS; VOLKOW ND; WANG GJ; PAPPAS N; LOGAN J; SHEA C; ALEXOFF D; MACGREGOR RR; SCHLYER DJ; ZEZULKOVA I; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 24, volume: 93, anno: 1996,
pagine: 14065 - 14069
SICI:
0027-8424(1996)93:24<14065:BMIICS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PARKINSONS-DISEASE; SMOKING CESSATION; MAJOR DEPRESSION; MOCLOBEMIDE; DOPAMINE; TOBACCO; BINDING; SYSTEM; HEAVY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Fowler et al., "BRAIN MONOAMINE-OXIDASE-A INHIBITION IN CIGARETTE SMOKERS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(24), 1996, pp. 14065-14069

Abstract

Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis that MAO A would be reduced in the brain of cigarette smokers. We compared brain MAO A in 15 nonsmokers and 16 current smokers with [C-11]clorgyline and positron emission tomography (PET). Four of the nonsmokers werealso treated with the antidepressant MAO inhibitor drug, tranylcypromine (10 mg/day for 3 days) after the baseline PET scan and then rescanned to assess the sensitivity of [C-11]clorgyline binding to MAO inhibition. MAO A levels were quantified by using the model term lambda k(3) which is a function of brain MAO A concentration. Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%). The mean lambda k(3) values for the whole brain were 0.18 +/- 0.04 and 0.13 +/- 0.03 cc(brain) (ml(plasma))(-1) min(-1) for nonsmokers and smokers, respectively; P < 0.0003). Tranylcypromine treatment reduced lambda k(3) by an average of 58% for the different brain regions. Our results show that tobacco smoke exposure isassociated with a marked reduction in brain MAO A, and this reductionis about half of that produced by a brief treatment with tranylcypromine. This suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation.

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Documento generato il 01/04/20 alle ore 19:37:34