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Titolo:
MULTIPLE LYMPHOMATOUS POLYPOSIS OF THE GASTROINTESTINAL-TRACT - PROSPECTIVE CLINICOPATHOLOGICAL STUDY OF 31 CASES
Autore:
RUSKONEFOURMESTRAUX A; DELMER A; LAVERGNE A; MOLINA T; BROUSSE N; AUDOUIN J; RAMBAUD JC; MATUCHANSKY C; MESSING B; BOUHNIK Y; BITOUN A; COSNES J; CARBONNEL F; GENDRE JP; JIAN R; LEMANN M; MODIGLIANI R; PESCATORE P; RIO B; ZITTOUN R; GRANGE JD; OPOLON P; BUFFET C; PRAT F; PELLETIER G; EUGENE C; BORUCHOWICHZ A; COLOMBEL JF; LOUVET H; LEGOUX JL; LEBODIC L; GALMICHE JP; LEMAIRE R;
Indirizzi:
HOP HOTEL DIEU,SERV MED INTERNE,DEPT GASTROENTEROL,1 PL PARVIS NOTRE DAME F-75181 PARIS 4 FRANCE HOP HOTEL DIEU,DEPT PATHOL F-75181 PARIS 4 FRANCE HOP HOTEL DIEU,DEPT HEMATOL F-75181 PARIS 4 FRANCE HOP LARIBOISIERE,DEPT PATHOL PARIS FRANCE HOP NECKER ENFANTS MALAD,DEPT PATHOL PARIS FRANCE HOP ST LAZARE,DEPT GASTROENTEROL PARIS FRANCE FDN FRANCAISE CANCEROL DIGEST DIJON FRANCE
Titolo Testata:
Gastroenterology
fascicolo: 1, volume: 112, anno: 1997,
pagine: 7 - 16
SICI:
0016-5085(1997)112:1<7:MLPOTG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANTLE CELL LYMPHOMA; NON-HODGKINS-LYMPHOMA; ZONE LYMPHOMA; MALIGNANT-LYMPHOMA; MESSENGER-RNA; EXPRESSION; PROGNOSIS; TISSUE; GUT; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
A. Ruskonefourmestraux et al., "MULTIPLE LYMPHOMATOUS POLYPOSIS OF THE GASTROINTESTINAL-TRACT - PROSPECTIVE CLINICOPATHOLOGICAL STUDY OF 31 CASES", Gastroenterology, 112(1), 1997, pp. 7-16

Abstract

Background & Aims: Multiple lymphomatous polyposis (MLP) is an uncommon type of gastrointestinal lymphoma. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients, Methods: From 1984 to 1995, 31 patients were enrolled prospectively, Exhaustive staging and immunohistochemical analysis were performed. The first 10 patients were treated with cyclophosphamide-vincristine-prednisolone (COP) and the subsequent 21 with xorubicin-teniposide-cyclophosphamide-prednisolone (AVmCP). Eleven patients were treated with high-dose radiochemotherapy and stem cell autotransplantation because of partial response or relapse. Results: Advanced age and multiple polyps involving several gastrointestinal segments characterized initial clinical presentation. The typical tumor cell phenotype (pan-B+, CD5(+), and CD10(-)) along with Bcl-1 rearrangement indicated that MLPis the gastrointestinal counterpart of mantle cell lymphoma. After COP treatment, only 3 patients achieved partial remissions, whereas 80% of patients after AVmCP treatment achieved complete or good partial remission. High-dose radiochemotherapy changed partial into complete remission in 80% of cases. None of the initial 10 patients survived for 3years, but the expected 5-year survival rate was 59% in patients receiving the anthracycline-containing regimen (P < 0.0001). Conclusions: MLP is a distinct entity among gastrointestinal lymphomas. An anthracycline-containing multidrug regimen and high-dose radiochemotherapy supported by autotransplantation seem to improve its poor prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:16:14