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Titolo:
GENDER DIFFERENCES IN SERUM LEPTIN LEVELS IN HUMANS
Autore:
HICKEY MS; ISRAEL RG; GARDINER SN; CONSIDINE RV; MCCAMMON MR; TYNDALL GL; HOUMARD JA; MARKS RHL; CARO JF;
Indirizzi:
E CAROLINA UNIV,HUMAN PERFORMANCE LAB,SCH MED GREENVILLE NC 27858 E CAROLINA UNIV,DEPT BIOCHEM,SCH MED GREENVILLE NC 27858 COLORADO STATE UNIV,DEPT EXERCISE & SPORT SCI FT COLLINS CO 80523 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT MED,DIV ENDOCRINOL & METAB PHILADELPHIA PA 19107 ELI LILLY & CO,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Biochemical and molecular medicine
fascicolo: 1, volume: 59, anno: 1996,
pagine: 1 - 6
SICI:
1077-3150(1996)59:1<1:GDISLL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE; ADIPOSE-TISSUE; MESSENGER-RNA; DB GENE; MICE; SUSCEPTIBILITY; EXPRESSION; MOUSE; SENSITIVITY; ADIPOCYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Hickey et al., "GENDER DIFFERENCES IN SERUM LEPTIN LEVELS IN HUMANS", Biochemical and molecular medicine, 59(1), 1996, pp. 1-6

Abstract

Leptin, the product of the ob gene, is an adipose tissue-derived hormone that appears to regulate both satiety and thermogenesis. In the present report, we have reexamined the relationship between circulating leptin concentration and body fat in humans using a more valid measureof adiposity (hydrodensitometry) and have extended these observationsto examine the influence of regional body fat distribution and cardiorespiratory fitness. Fasting serum leptin concentration was 6.9 +/- 0.3 ng . ml(-1) in males (N = 333) and 15.2 +/- 1.3 ng . ml(-1) in females (N = 63). Interestingly, total fat mass did not differ between groups (males 20.5 +/- 0.5 kg; females 20.4 +/- 1.5 kg), suggesting that females have higher leptin levels per unit fat mass. In a multiple regression model, fat mass was the best predictor of serum leptin concentration in males, accounting for 51% of the variance in leptin concentration. In females, percentage body fat was the best predictor of leptin, accounting for 49% of the variance. In both groups, the relationshipbetween leptin and adiposity remained significant after adjusting forage, maximal treadmill time, waist circumference, and fasting insulinconcentration. These observations support previous conclusions that circulating leptin is primarily a function of adiposity and demonstratefor the first time that this relationship is independent of fat distribution or cardiorespiratory fitness. The data also suggest that thereis a gender dichotomy in the relationship between leptin and body fatmass in humans. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:59:18