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Titolo:
SIGNAL-TRANSDUCTION PATHWAYS IN APOPTOSIS
Autore:
MCCONKEY DJ; ORRENIUS S;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,1515 HOLCOMBE BLVD HOUSTON TX 77030 KAROLINSKA INST,INST ENVIRONM MED S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Stem cells
fascicolo: 6, volume: 14, anno: 1996,
pagine: 619 - 631
SICI:
1066-5099(1996)14:6<619:SPIA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; PROTEIN-KINASE-C; ENDOGENOUS ENDONUCLEASE ACTIVATION; CERAMIDE-INDUCED APOPTOSIS; COLONY-STIMULATING FACTOR; INDUCED THYMOCYTE APOPTOSIS; RADIATION-INDUCED APOPTOSIS; CEREBELLAR GRANULE NEURONS; LYMPHOCYTIC-LEUKEMIA-CELLS; KILLS IMMATURE THYMOCYTES;
Keywords:
APOPTOSIS; CALCIUM; PKC; CAMP; CERAMIDE; CYCLIN-DEPENDENT KINASES; ENDONUCLEASE; PROTEASE; BCL-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
173
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Mcconkey e S. Orrenius, "SIGNAL-TRANSDUCTION PATHWAYS IN APOPTOSIS", Stem cells, 14(6), 1996, pp. 619-631

Abstract

Emerging evidence indicates that apoptosis is regulated by some of the same signal transduction pathways previously implicated in other physiological cellular responses, including alterations in intracellular Ca2+ compartmentalization, activation of protein kinases and phosphatases, alterations in pH and oxidative stress. interestingly, signals that promote apoptosis in one model can suppress cell death in another, indicating that cellular responses are determined by the intrinsic programming of the cell in question. This review will summarize current knowledge of the signal transduction pathways regulating apoptosis and discuss how they mag be coupled to components of the molecular machinery for cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:07:57