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Titolo:
ACCURACY OF CLINICAL-DIAGNOSIS OF ALZHEIMER-DISEASE AND CLINICAL-FEATURES OF PATIENTS WITH NON-ALZHEIMER DISEASE NEUROPATHOLOGY
Autore:
RASMUSSON DX; BRANDT J; STEELE C; HEDREEN JC; TRONCOSO JC; FOLSTEIN MF;
Indirizzi:
NIA,GERONTOL RES CTR,LAB PERSONAL & COGNIT,4940 EASTERN AVE,BOX 03 BALTIMORE MD 21224 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,NEUROPATHOL LAB BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21205
Titolo Testata:
Alzheimer disease and associated disorders
fascicolo: 4, volume: 10, anno: 1996,
pagine: 180 - 188
SICI:
0893-0341(1996)10:4<180:AOCOAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY DEGENERATIVE DEMENTIA; PROGRESSIVE DEMENTIA; NEUROFIBRILLARY TANGLES; HUNTINGTONS-DISEASE; PRESENILE-DEMENTIA; LOBAR ATROPHY; CRITERIA; CLASSIFICATION; CONSORTIUM; ESTABLISH;
Keywords:
ALZHEIMER DISEASE; DEMENTIA; DIAGNOSIS; NEUROPATHOLOGY; HIPPOCAMPAL SCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D.X. Rasmusson et al., "ACCURACY OF CLINICAL-DIAGNOSIS OF ALZHEIMER-DISEASE AND CLINICAL-FEATURES OF PATIENTS WITH NON-ALZHEIMER DISEASE NEUROPATHOLOGY", Alzheimer disease and associated disorders, 10(4), 1996, pp. 180-188

Abstract

Neuropathological examination confirmed the clinical diagnosis of possible or probable Alzheimer disease (AD) in 90 of the first 100 patients who came to autopsy at the Johns Hopkins Alzheimer's Disease Research Center. In 10 cases, postmortem brain examination did not confirm AD but revealed variable patterns of neuronal loss in neocortex and limbic structures without amyloid deposits. The most common pattern of degeneration was relatively isolated hippocampal sclerosis CHS). Despitethe finding that the 10 patients with non-AD neuropathology were ill for less time and were less cognitively impaired at study entry than those patients with definite AD, they had shorter survival times and showed equal behavioral disturbance at study entry (on a standardized measure). The clinical case reports included here suggest early and progressive prominent behavioral disturbance and other indexes of rapid illness progression in three of the four HS patients and two other non-AD patients. We conclude that the criteria of the National Institute ofNeurological Disorders and Stroke/Alzheimer Disease and Related Disorders Association for possible or probable AD are highly accurate and that misdiagnosis is most likely to occur early in the course of illness and in patients with prominent behavioral disturbance or other atypical features.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:45:46