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Titolo:
TRANSMURAL POTENTIAL CHANGES ASSOCIATED WITH THE IN-VITRO ABSORPTION OF THEANINE IN THE GUINEA-PIG INTESTINE
Autore:
KITAOKA S; HAYASHI H; YOKOGOSHI H; SUZUKI Y;
Indirizzi:
UNIV SHIZUOKA,SCH FOOD & NUTR SCI,PHYSIOL LAB,YADA 52-1 SHIZUOKA 422 JAPAN UNIV SHIZUOKA,SCH FOOD & NUTR SCI,PHYSIOL LAB SHIZUOKA 422 JAPAN UNIV SHIZUOKA,SCH FOOD & NUTR SCI,NUTR BIOCHEM LAB SHIZUOKA 422 JAPAN
Titolo Testata:
Bioscience, biotechnology, and biochemistry
fascicolo: 11, volume: 60, anno: 1996,
pagine: 1768 - 1771
SICI:
0916-8451(1996)60:11<1768:TPCAWT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BORDER MEMBRANE-VESICLES; TRANSPORT; GLUTAMINE; CELLS;
Keywords:
BRUSH-BORDER MEMBRANE; INTESTINAL ABSORPTION; JAPANESE GREEN TEA; AMINO ACID ABSORPTION; COTRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
S. Kitaoka et al., "TRANSMURAL POTENTIAL CHANGES ASSOCIATED WITH THE IN-VITRO ABSORPTION OF THEANINE IN THE GUINEA-PIG INTESTINE", Bioscience, biotechnology, and biochemistry, 60(11), 1996, pp. 1768-1771

Abstract

Theanine, L-N-ethylglutamine, is one of the major components of aminoacids in Japanese green tea. To characterize the mode for intestinal absorption of theanine, the ionic dependency and kinetic properties ofthe theanine- and glutamine-evoked transmural electrical potential difference changes (Delta PD) were investigated in vitro by using everted sacs prepared from the guinea pig ileum. Both theanine and glutamineapplied to the luminal side induced dose-dependent increases in DeltaPD (increase in serosal positive value). The theanine- and glutamine-evoked Delta PD values conformed to the Michaelis-Menten relationship,with Delta PDmax not being different, whereas the half-saturation concentration was lower for glutamine (3.1 +/- 0.2 mM) than for theanine (21.4 +/- 0.6 mM). The theanine-evoked Delta PD value was much smallerwhen theanine was applied in the presence of glutamine than when applied alone. The theanine- and glutamine-evoked Delta PD values were both inhibited by removing Na+ from the luminal solution. These results suggest that the intestinal absorption of theanine and glutamine is mediated by a common Na+-coupled co-transporter in the brush-border membrane, the affinity of which is lower for theanine than for glutamine.

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Documento generato il 01/12/20 alle ore 10:06:29