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Titolo:
LYMPHATIC MAPPING AND SENTINEL NODE BIOPSY IN THE PATIENT WITH BREAST-CANCER
Autore:
ALBERTINI JJ; LYMAN GH; COX C; YEATMAN T; BALDUCCI L; KU NN; SHIVERS S; BERMAN C; WELLS K; RAPAPORT D; SHONS A; HORTON J; GREENBERG H; NICOSIA S; CLARK R; CANTOR A; REINTGEN DS;
Indirizzi:
UNIV S FLORIDA,H LEE MOFFITT CANC CTR & RES INST,COMPREHENS BREAST CANC PROGRAM TAMPA FL 33612 UNIV S FLORIDA,H LEE MOFFITT CANC CTR & RES INST,COMPREHENS BREAST CANC PROGRAM TAMPA FL 33612
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 22, volume: 276, anno: 1996,
pagine: 1818 - 1822
SICI:
0098-7484(1996)276:22<1818:LMASNB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; EARLY-STAGE MELANOMA; MALIGNANT-MELANOMA; DISSECTION; METASTASES; MANAGEMENT; CARCINOMA; LYMPHADENECTOMY; MICROMETASTASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Albertini et al., "LYMPHATIC MAPPING AND SENTINEL NODE BIOPSY IN THE PATIENT WITH BREAST-CANCER", JAMA, the journal of the American Medical Association, 276(22), 1996, pp. 1818-1822

Abstract

Objectives.-To identify the sentinel lymph node(s) (SLN[s]) (the first node[s] draining the primary tumor in the regional lymphatic basin) in patients with invasive breast cancer and to test the hypothesis that the histologic characteristics of the SLN predict the histologic characteristics of the remaining lymph nodes in the axilla. Design.-A prospective trial. Participants.-Sixty-two patients with newly diagnosed invasive breast cancers.Intervention.-Patients underwent intraoperative lymphatic mapping using a combination of a vital blue dye and filtered technetium-labeled sulfur colloid. The SLN was identified and removed, followed by a definitive cancer operation, including a complete axillary node dissection. Main Outcome Measure The metastatic distribution in the axilla was determined in patients with occult nodal disease. Results.-The SLN was successfully identified in 57 (92%) of 62 patients using the 2 lymphatic mapping procedures. After focalization, 18 patients (32%) were found to have metastatic disease, and the SLN testedpositive in all 18 patients. There were no ''skip'' metastases, defined as an SLN that tested negative with higher nodes that tested positive. In 12 (67%) of 18 patients with metastatic disease, the SLN was the only site of disease. The metastatic distribution significantly favored SLN involvement. Among subjects with discordant nodal involvement,the probability of observing the distribution of SLN involvement by chance is very small (P<.001). Conclusions.-This study confirms that lymphatic mapping is technically possible in the patient with breast cancer and that the histologic characteristics of the SLN probably reflect the histologic characteristics of the rest of the axillary lymph nodes. The procedure also allows the pathologist to focus the histologic examination on 1 or 2 nodes, potentially increasing the yield of positive dissections and the accuracy of staging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:41:47