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Titolo:
LIPOPROTEIN(A) AND OTHER LIPIDS AFTER OOPHORECTOMY AND ESTROGEN REPLACEMENT THERAPY
Autore:
BRUSCHI F; MESCHIA M; SOMA M; PEROTTI D; PAOLETTI R; CROSIGNANI PG;
Indirizzi:
UNIV MILAN,DEPT OBSTET & GYNECOL,VIA COMMENDA 12 I-20122 MILAN ITALY UNIV MILAN,INST PHARMACOL SCI MILAN ITALY
Titolo Testata:
Obstetrics and gynecology
fascicolo: 6, volume: 88, anno: 1996,
pagine: 950 - 954
SICI:
0029-7844(1996)88:6<950:LAOLAO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; POSTMENOPAUSAL WOMEN; LP(A) LIPOPROTEIN; PLASMA; RISK; CHOLESTEROL; METABOLISM; FRAMINGHAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F. Bruschi et al., "LIPOPROTEIN(A) AND OTHER LIPIDS AFTER OOPHORECTOMY AND ESTROGEN REPLACEMENT THERAPY", Obstetrics and gynecology, 88(6), 1996, pp. 950-954

Abstract

Objective: To assess the effect of surgical menopause and subsequent estrogen replacement therapy (ERT) on lipoprotein(a) [Lp(a)] and common lipids. Methods: In 24 healthy premenopausal women, lipids (total cholesterol, low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and gonadotropins (FSH, LH) weremeasured the day before hysterectomy with bilateral oophorectomy and then after I, 2, and 3 months. blood was also drawn after 2, 4, 6, and15 days to exclude the effect of surgery on Lp(a). In 19 women who volunteered for ERT, the lipid profile was assayed again after 3, 6, and12 months of treatment. Results: Lipoprotein(a) levels rose significantly over the 3 months after surgery, from a mean +/- standard deviation (SD) 5.7 +/- 6.1 mg/dL to 10.4 +/- 9.2 mg/dL. Total cholesterol andLDL cholesterol levels increased significantly over the first 2 months; HDL cholesterol decreased significantly during the 3 months of follow-up (by 10, 17, and 20%) (P < .001). plasma triglycerides did not change after surgery. Three months following ERT, Lp(a) and total cholesterol were significantly decreased (28 and 11%, respectively), as was LDL cholesterol (33% after 6 months. High-density lipoprotein cholesterol increased by 24% after 6 months of treatment, and triglycerides rose significantly in the year of therapy (37%). Conclusion: These findings suggest that surgical menopause induces atherogenic changes in thelipid profile in 3 months and that ERT soon reverses them. Copyright (C) by The American College of Obstetricians ann Gynecologists.

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Documento generato il 05/12/20 alle ore 07:03:30