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Titolo:
K-ATP CHANNEL OPENING DOES NOT CONTRIBUTE SIGNIFICANTLY TO THE VASODILATORY EFFECT OF SH-GROUP-CONTAINING ACE-INHIBITORS
Autore:
KOPPEL H; HOLZMANN S; KLEIN W; HORN E; HORN E; HORN S; GASSER R;
Indirizzi:
GRAZ UNIV,DEPT INTERNAL MED,AUENBRUGGERPL 15 A-8036 GRAZ AUSTRIA GRAZ UNIV,DEPT INTERNAL MED A-8036 GRAZ AUSTRIA
Titolo Testata:
Heart and vessels
fascicolo: 4, volume: 11, anno: 1996,
pagine: 192 - 196
SICI:
0910-8327(1996)11:4<192:KCODNC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL SMOOTH-MUSCLE; CONTRACTILE FAILURE; POTASSIUM; MECHANISMS; ISCHEMIA;
Keywords:
K-ATP CHANNEL; ACE INHIBITOR; CORONARY; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Koppel et al., "K-ATP CHANNEL OPENING DOES NOT CONTRIBUTE SIGNIFICANTLY TO THE VASODILATORY EFFECT OF SH-GROUP-CONTAINING ACE-INHIBITORS", Heart and vessels, 11(4), 1996, pp. 192-196

Abstract

Angiotensin-converting enzyme (ACE) inhibitors are widely used in themanagement of hypertension, heart failure, and nephropathy. It has been suggested thar ACE inhibitors containing the sulfhydryl group (SH) have an additional effect on K-ATP channels. To prove this hypothesis,we studied the effects of the SH-containing ACE inhibitors, captopriland zofenopril, on K-ATP channel opening of bovine coronary arteries and guinea pig thoracic aortas. Bovine coronary arteries were precontracted with the thromboxane: A2 analogue, U46619, and guinea pig thoracic aortas were prc contracted with phenylephrine and then relaxed witheither captopril or zofenopril (n = 8). Inhibition of K-ATP channel opening with glibenclamide moderately attenuated the zofenopril-inducedrelaxation of guinea pig thoracic aorta. However, in the bovine coronary arteries, the relaxing effect of both captopril and zofenopril remained uneffected by glibenclamide. In experiments: with enalapril (a non SH-containing ACE inhibitor: n = 6) on guinea pig thoracic aortas, no effect on K-ATP channels could be seen. From our experiments, we conclude that the postulated opening of K-ATP channels by SH-group-containing ACE inhibitors contributes little to the vasodilation of guinea pig thoracic aortas caused by ACE inhibitors, and that SH groups have no influence upon K-ATP channels of bovine coronary arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:50:14