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Titolo:
GENETIC-MAPPING AND CHROMOSOME LOCALIZATION OF THE RAT MITOCHONDRIAL GLYCEROL-3-PHOSPHATE DEHYDROGENASE GENE, A CANDIDATE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
KOIKE G; VANVOOREN P; SHIOZAWA M; GALLI J; LI LS; GLASER A; BALASUBRAMANYAM A; BROWN LJ; LUTHMAN H; SZPIRER C; MACDONALD MJ; JACOB HJ;
Indirizzi:
MED COLL WISCONSIN,DEPT PHYSIOL,8701 WATERTOWN PLANK RD,POB 26509 MILWAUKEE WI 53226 MASSACHUSETTS GEN HOSP EAST,CARDIOVASC RES CTR CHARLESTOWN MA 02129 FREE UNIV BRUSSELS,DEPT BIOL MOL B-1640 RHODE ST GENESE BELGIUM KAROLINSKA HOSP,DEPT MOL MED,ROLF LUFT CTR DIABET RES S-17176 STOCKHOLM SWEDEN UNIV WISCONSIN,SCH MED,CHILDREN DIABET CTR MADISON WI 53706
Titolo Testata:
Genomics
fascicolo: 1, volume: 38, anno: 1996,
pagine: 96 - 99
SICI:
0888-7543(1996)38:1<96:GACLOT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED GLYCEROPHOSPHATE DEHYDROGENASE; LINKAGE MAP; ISLETS; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
G. Koike et al., "GENETIC-MAPPING AND CHROMOSOME LOCALIZATION OF THE RAT MITOCHONDRIAL GLYCEROL-3-PHOSPHATE DEHYDROGENASE GENE, A CANDIDATE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS", Genomics, 38(1), 1996, pp. 96-99

Abstract

The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesisof non-insulin-dependent diabetes mellitus (NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto-Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker for Gpd2 was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescence in situ hybridization was also carried out to verify the map position. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:32:53