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Titolo:
PATTERN OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN THE OVINE UTERUS DURING THE ESTROUS-CYCLE AND PREGNANCY
Autore:
YANG K; FRASER M; YU M; KRKOSEK M; CHALLIS JRG; LAMMING GE; CAMPBELL LE; DARNEL A;
Indirizzi:
UNIV WESTERN ONTARIO,ST JOSEPHS HOSP,LAWSON RES INST,DEPT OBSTET GYNECOL,268 GROSVENOR ST LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HOSP,LAWSON RES INST,DEPT PHYSIOL LONDON ON N6A 4V2 CANADA UNIV TORONTO,MRC,DEPT PHYSIOL,GRP FETAL & NEONATAL HLTH & DEV TORONTOON M5S 1A8 CANADA UNIV NOTTINGHAM,DEPT PHYSIOL & ENVIRONM SCI LOUGHBOROUGH LE12 5RD LEICS ENGLAND
Titolo Testata:
Biology of reproduction
fascicolo: 6, volume: 55, anno: 1996,
pagine: 1231 - 1236
SICI:
0006-3363(1996)55:6<1231:PO1DTM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL; CORTISOL; TISSUE; RNA; INTERCONVERSION; PARTURITION; SECRETION; DECIDUA; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Yang et al., "PATTERN OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN THE OVINE UTERUS DURING THE ESTROUS-CYCLE AND PREGNANCY", Biology of reproduction, 55(6), 1996, pp. 1231-1236

Abstract

The present study was designed to examine the pattern and cellular localization of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) gene expression in the ovine uterus during pregnancy and at 3 mo postpartum. High levels of 11 beta-HSD1 mRNA were detected in the endometrium from Days 60 to 143 (term = 145 days), and the levels did not change significantly during that time. The level of 11 beta-HSD1 mRNA inthe endometrium was always much higher than that in the myometrium, in which the mRNA was not readily detectable throughout pregnancy; at 3mo postpartum, 11 beta-HSD1 mRNA became undetectable in both endometrium and myometrium. Within the endometrium, intense immunoreactive 11 beta-HSD1 was localized exclusively to the luminal epithelium, and theintensity of 11 beta-HSD1 immunostaining closely followed the level of 11 beta-HSD1 mRNA. To determine whether the level of endometrial 11 beta-HSD1 mRNA was related to the status of ovarian function, tissues from nonpregnant animals at different stages of their reproductive cycle were also examined. It was found that 11 beta-HSD1 mRNA was undetectable in the endometrium of cycling animals up to Day 9 of the estrouscycle but was detectable thereafter. Taken together, these results demonstrate that within the ovine uterus the endometrium is always the dominant site of 11 beta-HSD1 gene expression in relation to the myometrium. Furthermore, the expression of 11 beta-HSD1 mRNA in the endometrium is closely related to the status of the reproductive cycle. The mRNA for 11 beta-HSD1 is highly expressed only during pregnancy and in nonpregnant animals during the late luteal phase. Since circulating levels of progesterone are elevated during both of these periods, the present findings suggest a progesterone effect on uterine 11 beta-HSD1 gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:40:09