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Titolo:
GASTRIC NON-HODGKIN LYMPHOMAS OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE ARE NOT ASSOCIATED WITH MORE AGGRESSIVE HELICOBACTER-PYLORI STRAINS AS IDENTIFIED BY CAGA
Autore:
DEJONG D; VANDERHULST RWM; PALS G; VANDIJK WC; VANDERENDE A; TYTGAT GNJ; TAAL BG; BOOT H;
Indirizzi:
NETHERLANDS CANC INST,DEPT PATHOL,PLESMANLAAN 121 NL-1066 CX AMSTERDAM NETHERLANDS NETHERLANDS CANC INST,DEPT GASTROENTEROL NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL & HEPATOL NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT MICROBIOL NL-1105 AZ AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,DEPT HUMAN GENET AMSTERDAM NETHERLANDS SLOTERVAARTZIEKENHUIS,DEPT MICROBIOL AMSTERDAM NETHERLANDS
Titolo Testata:
American journal of clinical pathology
fascicolo: 5, volume: 106, anno: 1996,
pagine: 670 - 675
SICI:
0002-9173(1996)106:5<670:GNLOML>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL-ULCER; MALT-TYPE; INFECTION; ERADICATION; CARCINOMA; STOMACH; RISK; REGRESSION; ANTIGEN; CANCER;
Keywords:
GASTRIC LYMPHOMA; MUCOSA-ASSOCIATED LYMPHOID TISSUE; HELICOBACTER PYLORI; CAGA; ONCOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D. Dejong et al., "GASTRIC NON-HODGKIN LYMPHOMAS OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE ARE NOT ASSOCIATED WITH MORE AGGRESSIVE HELICOBACTER-PYLORI STRAINS AS IDENTIFIED BY CAGA", American journal of clinical pathology, 106(5), 1996, pp. 670-675

Abstract

Primary gastric non-Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT-NHL) is strongly related to Helicobacter pylori (H pylori) infection. CagA positive H pylori strains appear to be more aggressive, as reflected by a greater degree of gastric inflammation and higher levels of Il-8 production. Using a polymerase chain reaction-based assay, cagA status was determined in H pylori strains of 12 patients withgastric MALT-NHL, 38 patients with peptic ulcer disease, and 39 patients with non-ulcer dyspepsia. CagA-positive H pylori strains were significantly more frequent in peptic nicer disease than in non-ulcer dyspepsia (Fisher's exact test p < 0.001), An increased frequency of CagA-positive strains was not identified in gastric MALT-NHL compared to non-ulcer dyspepsia patients (Fisher's exact test P < .3), Therefore, itcan be concluded that infection with more aggressive strains is associated with the development of peptic ulcer disease, but plays a minor role, if any, in the development of gastric MALT-NHL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:53:11