Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REINFORCEMENT PROCESSES IN OPIATE ADDICTION - A HOMEOSTATIC MODEL
Autore:
SCHULTEIS G; KOOB GF;
Indirizzi:
NEUROCRINE BIOSCI INC,NEUROSCI GRP,3050 SCI PK RD SAN DIEGO CA 92121 SCRIPPS CLIN & RES INST,DEPT NEUROPHARMACOL,DIV PSYCHOPHARMACOL LA JOLLA CA 00000
Titolo Testata:
Neurochemical research
fascicolo: 11, volume: 21, anno: 1996,
pagine: 1437 - 1454
SICI:
0364-3190(1996)21:11<1437:RPIOA->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID PHYSICAL-DEPENDENCE; CORTICOTROPIN-RELEASING FACTOR; MESOLIMBIC DOPAMINE SYSTEM; BRIEF MORPHINE EXPOSURE; OPPONENT-PROCESS THEORY; VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; DRUG-DEPENDENCE; PRECIPITATED WITHDRAWAL; ETHANOL WITHDRAWAL;
Keywords:
OPIATES; NEUROADAPTATION; DRUG DEPENDENCE; DRUG WITHDRAWAL; OPPONENT PROCESS; ADDICTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
133
Recensione:
Indirizzi per estratti:
Citazione:
G. Schulteis e G.F. Koob, "REINFORCEMENT PROCESSES IN OPIATE ADDICTION - A HOMEOSTATIC MODEL", Neurochemical research, 21(11), 1996, pp. 1437-1454

Abstract

The development of tolerance and dependence has traditionally been considered an integral aspect of the drug addiction process, and opiate dependence has been studied extensively as a model system in this regard. However, recent emphasis on the positive reinforcing properties ofdrugs has led to the suggestion that tolerance, dependence, and withdrawal may be of secondary or even negligible importance in motivating compulsive drug use. The current article argues for an integrated viewof addiction in the form df a homeostatic neuroadaptation model whichemphasizes the motivational significance of both the positive affective state produced by opiates and the negative affective state characteristic of drug withdrawal. The model is supported by evidence at both the behavioral and neural systems levels of analysis. Understanding the important distinction between somatic and affective components of opiate withdrawal is key to recognizing the factors which contribute to the motivational significance of opiate dependence and withdrawal. In addition, the critical role of conditioning processes in the maintenance of compulsive drug use and relapse after periods of abstention is discussed. Finally, it is argued that both the positive reinforcement produced by acute administration of a drug and the negative affective state produced by withdrawal are common to multiple classes of abused drugs, suggesting that an understanding of homeostatic neuroadaptation within motivational systems provides a key to the etiology, treatment and prevention of drug addiction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 08:17:56