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Titolo:
LAMINAR DISTRIBUTION OF THE MULTIPLE OPIOID RECEPTORS IN THE HUMAN CEREBRAL-CORTEX
Autore:
HILLER JM; FAN LQ;
Indirizzi:
NYU,MED CTR,DEPT PSYCHIAT,550 1ST AVE NEW YORK NY 10016
Titolo Testata:
Neurochemical research
fascicolo: 11, volume: 21, anno: 1996,
pagine: 1333 - 1345
SICI:
0364-3190(1996)21:11<1333:LDOTMO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN-REGIONS; KAPPA-OPIATE RECEPTOR; BINDING-SITES; ALZHEIMERS-DISEASE; FUNCTIONAL EXPRESSION; AUTORADIOGRAPHIC LOCALIZATION; CHROMOSOMAL ASSIGNMENT; ACETYLCHOLINE-RELEASE; SUICIDE VICTIMS; HUMAN FOREBRAIN;
Keywords:
HUMAN BRAIN; CEREBRAL CORTEX; MU DELTA, AND KAPPA OPIOID RECEPTORS; CORTICAL LAMINAE; RECEPTOR BINDING; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Hiller e L.Q. Fan, "LAMINAR DISTRIBUTION OF THE MULTIPLE OPIOID RECEPTORS IN THE HUMAN CEREBRAL-CORTEX", Neurochemical research, 21(11), 1996, pp. 1333-1345

Abstract

Quantitative autoradiographic assessment of cerebral cortical laminardistribution of mu, delta and kappa opioid receptors was carried out in coronal sections of five post-mortem human brains obtained at autopsy. The cortical areas studied were: cingulate, frontal, insular, parietal, parahippocampal, temporal occipitotemporal, occipital and striate area. In general, the laminar patterns of distribution for the threetypes of receptors are distinctive. Peak levels of delta opioid binding are in laminae I, II, and IIIa. mu-Receptors are located in lamina III followed by I and II in cingulate, frontal, insular and parietal cortices and lamina IV in temporal and occiptotemporal cortices. kappa-Receptors are found concentrated in laminae V and VI. The patterns of opioid binding in cortical laminae showed remarkable consistency in all five brains examined. In contrast to other cortical areas, the parahippocampal gyrus, at the level of the amygdaloid formation, demonstrated peak kappa receptor density in laminae I, II and III. mu-Opioid binding was undetectable in the lateral occipital cortex and in the striate area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:13:40