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Titolo:
SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CLOZAPINE AND NORCLOZAPINE IN HUMAN PLASMA
Autore:
FREEMAN DJ; LI MC; OYEWUMI K;
Indirizzi:
JOHN P ROBARTS RES INST,100 PERTH DR LONDON ON N6A 5K8 CANADA HOSP PSYCHIAT LONDON ON CANADA
Titolo Testata:
Therapeutic drug monitoring
fascicolo: 6, volume: 18, anno: 1996,
pagine: 688 - 692
SICI:
0163-4356(1996)18:6<688:SEAHLA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; PHARMACOKINETICS;
Keywords:
CLOZAPINE; NORCLOZAPINE; LIQUID CHROMATOGRAPHY; SOLID-PHASE EXTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Freeman et al., "SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CLOZAPINE AND NORCLOZAPINE IN HUMAN PLASMA", Therapeutic drug monitoring, 18(6), 1996, pp. 688-692

Abstract

A rapid high-performance liquid chromatographic method for the simultaneous quantitation of plasma clozapine and its principal metabolite, norclozapine, was developed using a Spherisorb C8 5-mu m reverse-phasecolumn and an acetonitrile/potassium phosphate buffer/triethylamine mobile phase. Clozapine and norclozapine were extracted from plasma on solid-phase reusable microcolumns. Absolute recovery of clozapine, norclozapine, and the internal standard, flurazepam, was quantitative. The mean intraassay coefficient of variation was better than 6% for clozapine and norclozapine at therapeutic concentrations. Based on a plasma sample volume of 200 mu l, the limit of accurate quantitation of both clozapine and norclozapine was similar to 25 mu g/L (coefficients ofvariation = 11.4% and 8.4%, respectively). The method has been used over the past 2 years for single-dose pharmacokinetic studies and for monitoring patients receiving clozapine therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:56:57