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Titolo:
COAGULATION-FACTOR-V GENE MUTATION INCREASES THE RISK OF VENOUS THROMBOSIS IN BEHCETS-DISEASE
Autore:
GUL A; OZBEK U; INANC M; KONICE M; OZCELIK T;
Indirizzi:
ZUHURATBAB MAH TURKIS CAD 14-8 TR-34740 BAKIRKOY ISTANBUL TURKEY ISTANBUL UNIV,INST EXPT MED,DEPT GENET ISTANBUL TURKEY BILKENT UNIV,FAC SCI,DEPT MOL BIOL & GENET ANKARA TURKEY ISTANBUL UNIV,ISTANBUL MED SCH,DEPT INTERNAL MED,DIV RHEUMATOL ISTANBUL TURKEY
Titolo Testata:
British journal of rheumatology
fascicolo: 11, volume: 35, anno: 1996,
pagine: 1178 - 1180
SICI:
0263-7103(1996)35:11<1178:CGMITR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; RESISTANCE; MANIFESTATIONS; DEFICIENCY;
Keywords:
BEHCETS DISEASE; FACTOR V GENE MUTATION; ACTIVATED PROTEIN C RESISTANCE; DEEP VEIN THROMBOSIS; VASCULITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Gul et al., "COAGULATION-FACTOR-V GENE MUTATION INCREASES THE RISK OF VENOUS THROMBOSIS IN BEHCETS-DISEASE", British journal of rheumatology, 35(11), 1996, pp. 1178-1180

Abstract

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygousstate in 37.5% of the patients with a history of deep vein thrombosis(12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation(10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the developmentof venous thrombosis in BD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:28:10