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Titolo:
HORMONE REPLACEMENT THERAPY IS ASSOCIATED WITH IMPROVED ARTERIAL PHYSIOLOGY IN HEALTHY POSTMENOPAUSAL WOMEN
Autore:
MCCROHON JA; ADAMS MR; MCCREDIE RJ; ROBINSON J; PIKE A; ABBEY M; KEECH AC; CELERMAJER DS;
Indirizzi:
UNIV SYDNEY,DEPT CARDIOL,ROYAL PRINCE ALFRED HOSP CAMPERDOWN NSW 2050AUSTRALIA UNIV SYDNEY,DEPT CARDIOL,ROYAL PRINCE ALFRED HOSP CAMPERDOWN NSW 2050AUSTRALIA ROYAL PRINCE ALFRED HOSP,DEPT OBSTET & GYNAECOL CAMPERDOWN NSW 2050 AUSTRALIA HEART RES INST CAMPERDOWN NSW AUSTRALIA CSIRO,DIV HUMAN NUTR ADELAIDE SA AUSTRALIA UNIV SYDNEY,NATL HLTH & MED RES COUNCIL,CLIN TRIALS CTR SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Clinical endocrinology
fascicolo: 4, volume: 45, anno: 1996,
pagine: 435 - 441
SICI:
0300-0664(1996)45:4<435:HRTIAW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; CORONARY-ARTERY; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; RISK-FACTORS; ESTROGEN; ATHEROSCLEROSIS; DISEASE; ACETYLCHOLINE; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Mccrohon et al., "HORMONE REPLACEMENT THERAPY IS ASSOCIATED WITH IMPROVED ARTERIAL PHYSIOLOGY IN HEALTHY POSTMENOPAUSAL WOMEN", Clinical endocrinology, 45(4), 1996, pp. 435-441

Abstract

OBJECTIVE Oestrogen replacement therapy is associated with a marked reduction in coronary event rates in post-menopausal women. As older age is associated with progressive arterial endothelial damage, a key event in atherosclerosis, we assessed whether hormone replacement therapy (HRT) with oestrogen alone, or oestrogen and progesterone combined, is associated with improved endothelial function in healthy women after the menopause. DESIGN Using high resolution external vascular ultrasound, brachial artery diameter was measured at rest and in response toreactive hyperaemia, with increased flow causing endothelium-dependent dilatation (flow-mediated dilatation). PATIENTS We investigated 135 healthy women; 40 were pre-menopausal (mean +/- SD age/26 +/- 6 years,group 1), 40 were post-menopausal and had never taken HRT (aged 58 +/- 3 years; group 2) and 55 were age-matched postmenopausal women who had taken HRT for greater than or equal to 2 years, from within 2 yearsof the menopause (aged 57 +/- 4 years; group 3). In group 3, 40 womenwere on combined oestrogen end progesterone and 15 on oestrogen-only HRT. RESULTS In group 2, flow-mediated dilatation was significantly reduced compared with group 1 (4.4 +/- 3.4 vs 9.6 +/- 3.6%, P < 0.001), consistent with a decline in arterial endothelial function after the menopause. In group 3, however, flow-mediated dilatation was significantly better than group 2 (6.2 +/- 3.3 vs 4.4 +/- 3.4%, P = 0.01), suggesting a protective effect of HRT. Flow-mediated dilatation was similarin women taking oestrogen alone and in those on combined HRT (5.5 +/-2.8 vs 6.5 +/- 3.4%, P = 0.40). CONCLUSIONS Long-term HRT is associated with improved arterial endothelial function in healthy post-menopausal women. This benefit was observed in both the combined hormone replacement and unopposed oestrogen therapy groups. This may explain some of the apparent cardioprotective effect of HRT after the menopause.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:59:35