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Titolo:
CELLULAR AND MOLECULAR ASPECTS OF MONOAMINE NEUROTRANSMITTER TRANSPORTERS
Autore:
KITAYAMA S; DOHI T;
Indirizzi:
HIROSHIMA UNIV,SCH MED,DEPT PHARMACOL,MINAMI KU,KOSUMI 1-2-3 HIROSHIMA 734 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 3, volume: 72, anno: 1996,
pagine: 195 - 208
SICI:
0021-5198(1996)72:3<195:CAMAOM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN DOPAMINE TRANSPORTER; GAMMA-AMINOBUTYRIC-ACID; PROTEIN-KINASE-C; PARKINSONISM-INDUCING NEUROTOXIN; HUMAN SEROTONIN TRANSPORTER; BETA-ADRENERGIC-RECEPTOR; PLACENTAL CHORIOCARCINOMA CELLS; RAT-BRAIN; MESSENGER-RNA; NOREPINEPHRINE-TRANSPORTER;
Keywords:
NEUROTRANSMITTER TRANSPORTER; MONOAMINE; ANTIDEPRESSANT; DRUG ABUSE; PARKINSONS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
125
Recensione:
Indirizzi per estratti:
Citazione:
S. Kitayama e T. Dohi, "CELLULAR AND MOLECULAR ASPECTS OF MONOAMINE NEUROTRANSMITTER TRANSPORTERS", Japanese Journal of Pharmacology, 72(3), 1996, pp. 195-208

Abstract

Neurotransmitter transporters terminate synaptic neurotransmission byaccumulating neurotransmitters once again after release in a sodium- and chloride-dependent fashion. The availability of the cloned neurotransmitter transporters has allowed investigation into the roles of these transporters in neuronal function. Molecular biological and proteinengineering studies including in vitro site-directed mutagenesis, chimera formation of several transporter clones, or epitope-tagging various regions of transporter proteins, have revealed the topology and functionally mapped the transporter proteins. Monoamine neurotransmitter transporters such as those for dopamine, norepinephrine and serotonin are of interest, since they are a target of drugs of abuse and are involved in neuronal disorders including Parkinson's disease and depression. Therefore, elucidating the molecular basis of these transporters may clarify these problems and help develop treatments with which to combat these disorders and drug abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 15:23:08