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Titolo:
COMPARISON OF THE IN-VITRO AND IN-VIVO PHARMACOLOGY OF ADRENOMEDULLIN, CALCITONIN-GENE-RELATED PEPTIDE AND AMYLIN IN RATS
Autore:
VINE W; BEAUMONT K; GEDULIN B; PITTNER R; MOORE CX; RINK TJ; YOUNG AA;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121 AMYLIN PHARMACEUT INC SAN DIEGO CA 92121
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 314, anno: 1996,
pagine: 115 - 121
SICI:
0014-2999(1996)314:1-2<115:COTIAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; HYPOTENSIVE PEPTIDE; CGRP RECEPTORS; ANTAGONISTS; RESPONSES; CLONING; AMIDE;
Keywords:
ADRENOMEDULLIN; AMYLIN; CGRP (CALCITONIN GENE-RELATED PEPTIDE); (RAT); LACTATE; CALCIUM; GASTRIC EMPTYING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W. Vine et al., "COMPARISON OF THE IN-VITRO AND IN-VIVO PHARMACOLOGY OF ADRENOMEDULLIN, CALCITONIN-GENE-RELATED PEPTIDE AND AMYLIN IN RATS", European journal of pharmacology, 314(1-2), 1996, pp. 115-121

Abstract

Adrenomedullin has been reported to be structurally similar to a group of peptides that includes amylin, calcitonin and calcitonin gene-related peptide (CGRP). Human and rat adrenomedullin displaced [I-125]CGRP from membranes of SK-N-MC cells (CGRP receptors) with affinities intermediate between those of rat amylin and rat CGRP alpha (K-i values 0.12 +/- 0.06, 0.017 +/- 0.007, 3.83 +/- 1.14 and 0.007 +/- 0.001 nM, respectively). In contrast, K-i values for displacement of [I-125]rat amylin from. nucleus accumbens membranes (amylin receptors), and [I-125]salmon calcitonin from T47D cells (calcitonin receptors) were lower than with rat amylin or rat CGRP alpha in these preparations (51 +/- 5,34 +/- 2, 0.024 +/- 0.002, 0.31 +/- 0.07 nM, respectively, at amylin receptors; 33 +/- 5, 69 +/- 29, 2.7 +/- 1.5 and 13 +/- 3 nM, respectively, at calcitonin receptors). In anesthetized rats, the hypotensive potency of adrenomedullin was between that of amylin and CGRP alpha. Incontrast, for amylin or calcitonin agonist actions (inhibition of [C-14]glycogen formation in soleus muscle, hyperlactemia, hypocalcemia and inhibition of gastric emptying), human adrenomedullin was without measurable effect. Thus, in its binding behaviour and in its biological actions, adrenomedullin appeared to behave as a potent CGRP agonist, but as a poor amylin or calcitonin agonist.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:18:08