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Titolo:
CONTINUOUS DEEP INTRAVENOUS-INFUSION IN RAT FERTILITY STUDIES
Autore:
BARROW PC; HERITIER B; MARSDEN E;
Indirizzi:
PHARMAKON EUROPE,ONCINS BP 118 F-69593 ARBRESLE FRANCE
Titolo Testata:
Toxicology methods
fascicolo: 3, volume: 6, anno: 1996,
pagine: 139 - 147
SICI:
1051-7235(1996)6:3<139:CDIIRF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Keywords:
CHRONIC INTRAVENOUS INFUSION; FERTILITY; MATING; SEXUAL BEHAVIOR; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Barrow et al., "CONTINUOUS DEEP INTRAVENOUS-INFUSION IN RAT FERTILITY STUDIES", Toxicology methods, 6(3), 1996, pp. 139-147

Abstract

Long-term intravenous (IV) infusion could be an important tool in toxicological testing for effects on fertility and sexual behavior. An experiment was performed to evaluate the feasibility of performing fertility studies in male and female rats using continuous deep IV infusion. A Silastic catheter was implanted in the inferior vena cava of 20 male and 20 female SD rats. The implanted rats were then continuously infused with sterile isotonic glucose solution. The females were infusedfor 2 weeks before mating with untreated males, after which infusion continued until termination on day 18 +/- 1 of gestation. Blood samples were taken from the pregnant females for clinical pathology investigations. The implanted males were treated for 4 weeks before successivepairing with 2 untreated females, Litter data were recorded followingcaesarean section of the mated females. The only adverse effects found were a slight transient reduction in weight gain of the infused females at the start of gestation and minor effects on food consumption, Fertility and fecundity of the infused rats were normal.

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Documento generato il 02/07/20 alle ore 19:13:27