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Titolo:
BASE-LINE STARTLE AMPLITUDE AND PREPULSE INHIBITION IN VIETNAM VETERANS WITH POSTTRAUMATIC-STRESS-DISORDER
Autore:
GRILLON C; MORGAN CA; SOUTHWICK SM; DAVIS M; CHARNEY DS;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,40 TEMPLE ST,GERU NEW HAVEN CT 06510 DEPT VET AFFAIRS MED CTR,NATL CTR POSTTRAUMAT STRESS DISORDER W HAVENCT 06516
Titolo Testata:
Psychiatry research
fascicolo: 3, volume: 64, anno: 1996,
pagine: 169 - 178
SICI:
0165-1781(1996)64:3<169:BSAAPI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE; PHYSIOLOGICAL-RESPONSES; SCHIZOPHRENIC-PATIENTS; REFLEX MODIFICATION; LOUD TONES; SENSITIZATION; MODULATION; MATURATION; SCALE; FEAR;
Keywords:
PSYCHOPHYSIOLOGY; AROUSAL; ACOUSTIC STARTLE REFLEX; EYEBLINK REFLEX; ANXIETY DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C. Grillon et al., "BASE-LINE STARTLE AMPLITUDE AND PREPULSE INHIBITION IN VIETNAM VETERANS WITH POSTTRAUMATIC-STRESS-DISORDER", Psychiatry research, 64(3), 1996, pp. 169-178

Abstract

Although an exaggerated startle response is a symptom of posttraumatic stress disorder (PTSD), empirical support for elevated baseline startle in PTSD has been weak. The present study investigated the eyeblinkcomponent of the acoustic startle reflex and prepulse inhibition (PPI) in 21 unmedicated Vietnam veterans with PTSD and in 17 civilian and 10 combat veteran comparison subjects. Patients with PTSD exhibited normal acoustic startle amplitude, but showed a significant reduction inPPI relative to the civilian subjects. There was only a trend toward a reduction in PPI in the PTSD group compared with the combat control group. The study does not support the hypothesis of exaggerated baseline startle in Vietnam veterans with PTSD but suggests abnormal startlemodulation by a prepulse (i.e., PPI). Discrepancies between studies concerning the amplitude of startle in PTSD are discussed.

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Documento generato il 19/01/20 alle ore 20:15:32