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Titolo:
EFFECTS OF DOPAMINE ANTAGONISTS IN A 2 WAY ACTIVE-AVOIDANCE PROCEDUREIN RATS - INTERACTIONS WITH 8-OH-DPAT, RITANSERIN, AND PRAZOSIN
Autore:
PRINSSEN EPM; KLEVEN MS; KOEK W;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81106 CASTRES FRANCE
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 128, anno: 1996,
pagine: 191 - 197
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; HALOPERIDOL-INDUCED CATALEPSY; NEUROLEPTIC DRUGS; PAW TEST; SCHIZOPHRENIC-PATIENTS; PATHO-PHYSIOLOGY; DOUBLE-BLIND; CLOZAPINE; RECEPTORS; RISPERIDONE;
Keywords:
SCHIZOPHRENIA; NEUROLEPTICS; DOPAMINE; D-2 RECEPTOR; SEROTONIN 5-HT2 RECEPTOR; ALPHA(1)-ADRENOCEPTOR; CONDITIONED AVOIDANCE RESPONSE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
E.P.M. Prinssen et al., "EFFECTS OF DOPAMINE ANTAGONISTS IN A 2 WAY ACTIVE-AVOIDANCE PROCEDUREIN RATS - INTERACTIONS WITH 8-OH-DPAT, RITANSERIN, AND PRAZOSIN", Psychopharmacology, 128(2), 1996, pp. 191-197

Abstract

Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter theeffects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The alpha(1)-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D-2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT1A agonists and neuroleptics, and support the hypothesis that combined5-HT1A agonist/D-2-like antagonist properties may be of clinical importance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:14:05