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Titolo:
A NOVEL MEMBRANE GLYCOPROTEIN, SHPS-1, THAT BINDS THE SH2-DOMAIN-CONTAINING PROTEIN-TYROSINE-PHOSPHATASE SHP-2 IN RESPONSE TO MITOGENS AND CELL-ADHESION
Autore:
FUJIOKA Y; MATOZAKI T; NOGUCHI T; IWAMATSU A; YAMAO T; TAKAHASHI N; TSUDA M; TAKADA T; KASUGA M;
Indirizzi:
KOBE UNIV,SCH MED,DEPT INTERNAL MED 2,CHUO KU,KUSUNOKI CHO KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT INTERNAL MED 2,CHUO KU KOBE 650 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL,KANAZAWA KU YOKOHAMA KANAGAWA 236 JAPAN
Titolo Testata:
Molecular and cellular biology
fascicolo: 12, volume: 16, anno: 1996,
pagine: 6887 - 6899
SICI:
0270-7306(1996)16:12<6887:ANMGST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SRC HOMOLOGY-2 DOMAINS; SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE; FACTOR RECEPTOR-BETA; GROWTH-FACTOR; SIGNAL-TRANSDUCTION; INSULIN-RECEPTOR; SH2 DOMAINS; MAP KINASE; MOTH-EATEN; PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
Y. Fujioka et al., "A NOVEL MEMBRANE GLYCOPROTEIN, SHPS-1, THAT BINDS THE SH2-DOMAIN-CONTAINING PROTEIN-TYROSINE-PHOSPHATASE SHP-2 IN RESPONSE TO MITOGENS AND CELL-ADHESION", Molecular and cellular biology, 16(12), 1996, pp. 6887-6899

Abstract

Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src homolog 2 (SH2) domains play important roles in growth factor and cytokine signal transduction pathways, A protein of similar to 115 to 120 kDa that interacts with SHP-1 and SHP-2 was purified from v-src-transformed rat fibroblasts (SR-3Y1 cells), and the corresponding cDNA was cloned. The predicted amino acid sequence of the encoded protein, termed SHPS-1 (SHP substrate 1), suggests that it is a glycosylated receptor-like protein with three immunoglobulin-like domains inits extracellular region and four YXX(L/V/I) motifs, potential tyrosine phosphorylation and SH2-domain binding sites, in its cytoplasmic region, Various mitogens, including serum, insulin, and lysophosphatidicacid, or cell adhesion induced tyrosine phosphorylation of SHPS-1 andits subsequent association with SHP-2 in cultured cells, Thus, SHPS-1may be a direct substrate for both tyrosine kinases, such as the insulin receptor kinase or Src, and a specific docking protein for SH2-domain-containing PTPases, In addition, we suggest that SHPS-1 may be a potential substrate for SHP-2 and may function in both growth factor- and cell adhesion-induced cell signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:03:10