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Titolo:
THE EFFECTS OF HYPERINSULINEMIA ON MYOCARDIAL MASS - BLOOD-PRESSURE REGULATION AND CENTRAL HEMODYNAMICS IN RATS
Autore:
HOLMANG A; YOSHIDA N; JENNISCHE E; WALDENSTROM A; BJORNTORP P;
Indirizzi:
SAHLGRENS UNIV HOSP,WALLENBERG LAB,DEPT HEART & LUNG DIS S-41345 GOTHENBURG SWEDEN KURUMA UNIV,SCH MED,DEPT INTERNAL MED 3 FUKUOKA JAPAN SAHLGRENS UNIV HOSP,DEPT HISTOL S-41345 GOTHENBURG SWEDEN UMEA UNIV,DEPT MED UMEA SWEDEN
Titolo Testata:
European journal of clinical investigation
fascicolo: 11, volume: 26, anno: 1996,
pagine: 973 - 978
SICI:
0014-2972(1996)26:11<973:TEOHOM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; INSULIN SENSITIVITY; PROTEIN TURNOVER; HYPERTENSION; HYPERTROPHY; MUSCLE; HEART; RESISTANCE; LINK;
Keywords:
CARDIAC OUTPUT; INSULIN; MYOCARDIUM; PERIPHERAL RESISTANCE; STROKE VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Holmang et al., "THE EFFECTS OF HYPERINSULINEMIA ON MYOCARDIAL MASS - BLOOD-PRESSURE REGULATION AND CENTRAL HEMODYNAMICS IN RATS", European journal of clinical investigation, 26(11), 1996, pp. 973-978

Abstract

Left ventricular hypertrophy is a condition with high mortality. An association with insulin resistance and hyperinsulinaemia has recently been suggested. The aim of this study was to examine the effects of isolated hyperinsulinaemia on cardiac weight and haemodynamic regulation. Rats were exposed to hyperinsulinaemia for 7 weeks after adrenalectomy with corticosterone substitution and continuous infusion of propranolol to control counter-regulatory mechanism (n = 15) (AIP group). Hypoglycaemia was prevented by glucose in the drinking water. Hyperinsulinaemic (AIP) rats were heavier and had increased relative masses of the myocardium (left ventricle 17% and right ventricle 20%), kidneys andadipose tissues in comparison with normoinsulinaemic adrenalectomized, corticosterone- and propranolol-treated controls (AP) (n = 10). Blood pressure in the insulin-exposed animals, measured weekly by the tail-cuff method in conscious rats, was not different from (AP) controls over 5 weeks, but increased in the sixth week. At the end of the seventh experimental week, blood pressure measured intra-arterially was alsofound to be elevated. Heart rate was not changed but total peripheralresistance was about twice that of controls (P < 0.001). Cardiac output and stroke volume was 30-40% lower in the AIP rats (P < 0.05). It is concluded that exposure to elevated insulin levels with control of counter-regulating mechanisms from beta-adrenergic mechanisms and adrenals is not immediately followed by blood pressure elevation. It is, therefore, suggested that early onset of blood pressure elevation after insulin exposure might be caused by insulin counter-regulatory events,causing both insulin resistance and blood pressure elevation. The longterm adaptations may involve a direct influence by insulin as a 'trophic factor' on myocardial and on peripheral resistance vessels, followed by increased blood pressure, decreased cardiac output and stroke volume.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:32:41