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Titolo:
LYSOSOMAL HYDROLASES IN SERUM FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS
Autore:
COSTANZI E; BECCARI T; FRANCISCI D; ORLACCHIO A; TASSI C;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ MED LAB,VIA GIOCHETTO I-06126 PERUGIA ITALY UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ MED LAB I-06126 PERUGIA ITALY UNIV PERUGIA,DEPT MOL & CELLULAR BIOL,SECT BIOCHEM & MOL BIOL I-06126PERUGIA ITALY UNIV PERUGIA,INST INFECT DIS,MONTELUCE POLICLIN I-06126 PERUGIA ITALY
Titolo Testata:
Clinica chimica acta
fascicolo: 1, volume: 255, anno: 1996,
pagine: 57 - 65
SICI:
0009-8981(1996)255:1<57:LHISFH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-BETA-GLUCOSAMINIDASE; N-ACETYLHEXOSAMINIDASE; HEXOSAMINIDASE; FORMS; ISOENZYMES; DISEASE; URINE; ENZYMES;
Keywords:
LYSOSOMAL HYDROLASES; ISOENZYMES; HUMAN IMMUNODEFICIENCY VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
E. Costanzi et al., "LYSOSOMAL HYDROLASES IN SERUM FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS", Clinica chimica acta, 255(1), 1996, pp. 57-65

Abstract

beta-Hexosaminidase isoenzymes were separated by DEAF-cellulose chromatography in the serum of 23 patients infected with human immunodeficiency virus at different stage of the disease. Forms corresponding to hexosaminidase B, I and A were present in pathological sera. There is an increase in the percentage of hexosaminidase I in pathological sera,that could be used as an additional marker to monitor the clinical stage of the disease. Furthermore, total activities of some lysosomal enzymes were determined in these sera. Activities of beta-hexosaminidase, determined with 4-methylumbelliferyl-beta-N-acetylglucopyranoside substrate, alpha-mannosidase and beta-mannosidase were significantly higher in the serum of patients at the C3 stage of disease than in controls. No significant differences were observed in the activity of beta-hexosaminidase, determined with belliferyl-beta-N-acetylglucopyranoside-6-sulphate substrate, beta-glucuronidase and beta-galactosidase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:29:36