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Titolo:
SERUM IGE LEVELS, ATOPY, AND ASTHMA IN YOUNG-ADULTS - RESULTS FROM A LONGITUDINAL COHORT STUDY
Autore:
PEAT JK; TOELLE BG; DERMAND J; VANDENBERG R; BRITTON WJ; WOOLCOCK AJ;
Indirizzi:
ROYAL PRINCE ALFRED HOSP,INST RESP MED SYDNEY NSW 2050 AUSTRALIA UNIV SYDNEY,DEPT MED SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Allergy
fascicolo: 11, volume: 51, anno: 1996,
pagine: 804 - 810
SICI:
0105-4538(1996)51:11<804:SILAAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; HOUSE-DUST MITE; BRONCHIAL HYPERRESPONSIVENESS; CHILDHOOD ASTHMA; AIRWAY RESPONSIVENESS; RESPIRATORY SYMPTOMS; POPULATION-SAMPLE; RELATIVE RISKS; ALLERGENS; CHILDREN;
Keywords:
ADULTS; AIRWAY; ASTHMA; ATOPY; CHILDREN; IGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Peat et al., "SERUM IGE LEVELS, ATOPY, AND ASTHMA IN YOUNG-ADULTS - RESULTS FROM A LONGITUDINAL COHORT STUDY", Allergy, 51(11), 1996, pp. 804-810

Abstract

To explore the natural history of asthma and its relation to allergicresponses, we examined the relation between total serum IgE in early adulthood and a history of respiratory symptoms, airway hyperresponsiveness (AHR), and atopy during childhood. We studied 180 subjects aged 18-20 years who had been studied since the age of 8-10 years. We measured wheeze in the previous year by questionnaire, AHR by histamine inhalation test, atopy by skin prick tests, and serum IgE levels by immunoassay. Subjects with AHR in early adulthood had higher IgE levels (mean 257.0 IU/ml) than subjects With past AHR (mean 93.3 IU/ml) or with lifelong normal responsiveness (mean 67.6 IU/ml) (P < 0.001). Subjectswho had symptoms had higher IgE levels (mean 125.9 IU/ml) than ihose who were lifelong asymptomatic (mean 63.1 IU/ml) (P < 0.001). Recent wheeze, AHR, and allergic sensitization all had a positive relation iu serum IgE, but IgE was not more predictive of AHR than skin prick tests. Tile finding that young adults who are sensitized to common allergens are highly likely to have AHR even in the absence of symptoms is further evidence of the fundamental role of IgE-mediated responses in the natural history of AHR throughout childhood and into adulthood.

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Documento generato il 03/06/20 alle ore 02:49:52