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Titolo:
CHARACTERIZATION OF NOVEL CYSTEINE-RICH ANTIMICROBIAL PEPTIDES FROM SCORPION BLOOD
Autore:
EHRETSABATIER L; LOEW D; GOYFFON M; FEHLBAUM P; HOFFMANN JA; VANDORSSELAER A; BULET P;
Indirizzi:
INST BIOL MOL & CELLULAIRE,UPR 9022 CNRS,15 RUE RENE DESCARTES F-67084 STRASBOURG FRANCE INST BIOL MOL & CELLULAIRE,UPR 9022 CNRS F-67084 STRASBOURG FRANCE UNIV STRASBOURG 1,FAC CHIM,LAB SPECTROMETRIE MASSE BIOORGAN,URA 31 CNRS F-67008 STRASBOURG FRANCE MUSEUM NATL HIST NAT F-75005 PARIS FRANCE DIV BIOL GEN & ECOL,LAB ETUD & RECH ARTHROPODES IRRADIES F-75005 PARIS FRANCE
Titolo Testata:
The Journal of biological chemistry
fascicolo: 47, volume: 271, anno: 1996,
pagine: 29537 - 29544
SICI:
0021-9258(1996)271:47<29537:CONCAP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROCTONUS-MAURETANICUS-MAURETANICUS; INDUCIBLE ANTIBACTERIAL PEPTIDE; CRAB TACHYPLEUS-TRIDENTATUS; K+ CHANNELS; INSECT DEFENSINS; ALPHA-CONOTOXIN; HEBRAEUS VENOM; PURIFICATION; CHARYBDOTOXIN; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
L. Ehretsabatier et al., "CHARACTERIZATION OF NOVEL CYSTEINE-RICH ANTIMICROBIAL PEPTIDES FROM SCORPION BLOOD", The Journal of biological chemistry, 271(47), 1996, pp. 29537-29544

Abstract

We have isolated, from the hemolymph of unchallenged scorpions of thespecies Androctonus australis, three distinct antimicrobial peptides,which we have fully characterized by Edman degradation, electrospray ionization mass spectrometry, and matrix-assisted laser desorption/ionization mass spectrometry. Two are novel molecules: (i) androctonin, a25-residue peptide with two disulfide bridges, active against both bacteria (Gram-positive and Gram-negative) and fungi and showing marked sequence homology to tachyplesins and polyphemusins from horseshoe crabs; and (ii) buthinin, a 34-residue antibacterial (Gram-positive and Gram-negative) peptide with three disulfide bridges. The third peptide contains 37 residues and three disulfide bridges and clearly belongs to the family of anti-Gram-positive insect defensins, We have synthesized androctonin and explored its activity spectrum and mode of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:20:03