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Titolo:
RHYTHMIC FIRING OF MEDIAL SEPTUM NONCHOLINERGIC NEURONS
Autore:
SERAFIN M; WILLIAMS S; KHATEB A; FORT P; MUHLETHALER M;
Indirizzi:
CTR MED UNIV GENEVA,DEPT PHYSIOL,1 RUE MICHEL SERVET CH-1211 GENEVA 4SWITZERLAND CTR MED UNIV GENEVA,DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 75, anno: 1996,
pagine: 671 - 675
SICI:
0306-4522(1996)75:3<671:RFOMSN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL FOREBRAIN; THETA-ACTIVITY; DIAGONAL BAND; GUINEA-PIG; RAT-BRAIN; OSCILLATIONS; HIPPOCAMPUS; PROJECTIONS; CORTEX; CA1;
Keywords:
BASAL FOREBRAIN; GUINEA-PIG; RAT; 40 HZ OSCILLATIONS; HIPPOCAMPUS; THETA RHYTHM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Serafin et al., "RHYTHMIC FIRING OF MEDIAL SEPTUM NONCHOLINERGIC NEURONS", Neuroscience, 75(3), 1996, pp. 671-675

Abstract

The presence of theta rhythm(3) (5-10 Hz) in the hippocampus has beenshown to enable long-term potentiation,(12,18) a synaptic mechanism which has been proposed to underlie learning and memory. Medial septum cholinergic and GABAergic neurons that project to the hippocampus(7,11,17,24,26,34) have been hypothesized to play conjointly a major role in the genesis of this rhythm.(3,19,31) Building upon previous studies that have established the electrophysiological criteria for distinguishing cholinergic and non-cholinergic neurons in this area,(1,2,8,9,14,23) it is demonstrated here that medial septum non-cholinergic neurons, putatively GABAergic, have the ability to discharge in rhythmic clusters of action potentials occurring at frequencies ranging from 1 to 8Hz. Within the clusters, the firing frequency of action potentials varied between 13 and 57 Hz in a voltage-dependent manner. In addition, small voltage-dependent subthreshold membrane potential oscillations (16-54 Hz) were observed between clusters. Both subthreshold oscillations and clusters mere eliminated by tetrodotoxin at 1 mu M. These results indicate that non-cholinergic medial septum neurons could convey tothe hippocampus not only theta but also higher frequency rhythmicity in the beta-gamma range (20-60 Hz). Copyright (C) 1996 IBRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:57:46