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Titolo:
SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT-REJECTION IN MICE
Autore:
QIAN SG; LI W; LI YP; FU FM; LU LN; FUNG JJ; THOMSON AW;
Indirizzi:
UNIV PITTSBURGH,MED CTR,THOMAS E STARZL TRANSPLANTAT INST,15TH FLOOR,BIOMED SCI TOWER PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT MOL GENET & BIOCHEM PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT SURG PITTSBURGH PA 15213
Titolo Testata:
Transplantation
fascicolo: 12, volume: 62, anno: 1996,
pagine: 1709 - 1714
SICI:
0041-1337(1996)62:12<1709:SAOCIC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITS CYTOKINE PRODUCTION; HUMAN MONOCYTES; IN-VIVO; IL-10; CELLS; EXPRESSION; REJECTION; LYMPHOCYTES; ANTIBODIES; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Qian et al., "SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT-REJECTION IN MICE", Transplantation, 62(12), 1996, pp. 1709-1714

Abstract

Cellular interleukin-10 (cIL-10) has been shown to inhibit cytokine production by T helper type 1 (Th1) cells by blocking antigen presenting cell function, This activity has suggested that IL-10 might be useful in the treatment of transplant rejection. Stimulatory effects of IL-10 however, have also been observed both on T and B cell differentiation. In this study, we examined the influence of recombinant (r) mouse (m) IL-10 on heterotopic vascularized heart allograft survival in the B10(H2(b))-->C3H(H2(k)) strain combination that crosses both major histocompatibility complex (MHC) and non-MHC-histocompatibility antigen (non-MHC-HA) barriers, The influence of IL-10 was also examined in the B10.BR(H2(k))-->C3H combination with disparity at only non-MHC-HA loci, Postoperative intraperitoneal administration of IL-10 (100 mu g/d, days 0-6) significantly accelerated heart graft rejection both in the B10-->C3H (mean survival time [MST] 7.8+/-0.2 days; control MST 10.6+/-0.6 days; P<0.05) and the B10.BR-->C3H combination (MST 14.3+/-0.5 days; control MST 77.7+/-14.4 days), Ex vivo IL-10 perfusion of donor hearts for either 15 min or 2 hr did not affect subsequent graft survival, Immunologic monitoring of transplanted mice revealed that IL-10 treatment (100 mu g/d, i.p., days 0-6) increased both the circulating complement-dependent cytotoxic (CDC) antibody titer and splenic anti-donorcytotoxic T lymphocyte (CTL) activity measured up to 3 weeks posttransplant. These findings indicate that post transplant systemic administration of cIL-10 can promote vascularized allograft rejection, and that this may reflect stimulation both of B and T cell alloimmune responses.

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Documento generato il 19/09/20 alle ore 15:15:18